ethyl 2-[2-methyl-4-(p-tolyl)-spiro[[1,3]dioxolane-2,7]-5,6,7,8-tetrahydro-9-thia-1-aza-7-oxo-fluoren-3-yl]pentanoate

Base Information

Chemical Name:ethyl 2-[2-methyl-4-(p-tolyl)-spiro[[1,3]dioxolane-2,7]-5,6,7,8-tetrahydro-9-thia-1-aza-7-oxo-fluoren-3-yl]pentanoate
CAS No.:1256254-51-9
Molecular Formula:C₂₈H₃₃NO₄S
Molecular Weight:479.64
Hs Code.:

Synonyms:ethyl 2-[2-methyl-4-(p-tolyl)-spiro[[1,3]dioxolane-2,7]-5,6,7,8-tetrahydro-9-thia-1-aza-7-oxo-fluoren-3-yl]pentanoate

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Chemical Property of ethyl 2-[2-methyl-4-(p-tolyl)-spiro[[1,3]dioxolane-2,7]-5,6,7,8-tetrahydro-9-thia-1-aza-7-oxo-fluoren-3-yl]pentanoate

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Technology Process of ethyl 2-[2-methyl-4-(p-tolyl)-spiro[[1,3]dioxolane-2,7]-5,6,7,8-tetrahydro-9-thia-1-aza-7-oxo-fluoren-3-yl]pentanoate

There total 4 articles about ethyl 2-[2-methyl-4-(p-tolyl)-spiro[[1,3]dioxolane-2,7]-5,6,7,8-tetrahydro-9-thia-1-aza-7-oxo-fluoren-3-yl]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 158038-41-6
ethyl 4-oxo-2-propylpentanoate

: 1256257-13-2
(2-amino-5,7-dihydro-4H-spiro[benzo[b]thiophene-6,2'-[1,3]dioxolane]-3-yl)(p-tolyl)methanone

: 1256254-51-9
ethyl 2-[2-methyl-4-(p-tolyl)-spiro[[1,3]dioxolane-2,7]-5,6,7,8-tetrahydro-9-thia-1-aza-7-oxo-fluoren-3-yl]pentanoate

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 72h; Inert atmosphere; Sealed tube;

Reference yield:

: 941-43-5
Ethyl levulinate ethylene ketal

: 1256254-51-9
ethyl 2-[2-methyl-4-(p-tolyl)-spiro[[1,3]dioxolane-2,7]-5,6,7,8-tetrahydro-9-thia-1-aza-7-oxo-fluoren-3-yl]pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 5.5 h / 20 °C

2.1: boron tribromide / hexane; dichloromethane / -78 - -20 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 72 h / 100 °C / Inert atmosphere; Sealed tube

With boron tribromide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 712265-71-9
ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)pentanoate

: 1256254-51-9
ethyl 2-[2-methyl-4-(p-tolyl)-spiro[[1,3]dioxolane-2,7]-5,6,7,8-tetrahydro-9-thia-1-aza-7-oxo-fluoren-3-yl]pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / hexane; dichloromethane / -78 - -20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 72 h / 100 °C / Inert atmosphere; Sealed tube

With boron tribromide; In hexane; dichloromethane; N,N-dimethyl-formamide;