2-[3-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-4-methyl-pentanoic acid

Base Information

Chemical Name:2-[3-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-4-methyl-pentanoic acid
CAS No.:223270-80-2
Molecular Formula:C₁₅H₂₇NO₆
Molecular Weight:317.382
Hs Code.:

2-[3-(<i>tert</i>-butoxycarbonyl-methyl-amino)-propionyloxy]-4-methyl-pentanoic acid

Synonyms:2-[3-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-4-methyl-pentanoic acid

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Chemical Property of 2-[3-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-4-methyl-pentanoic acid

Chemical Property:

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Technology Process of 2-[3-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-4-methyl-pentanoic acid

There total 1 articles about 2-[3-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 223270-80-2
2-[3-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / PhI(OAc)2, I₂ / -10 °C

2: EDCI, DMAP, TEA

3: H₂ / 10 percent Pd/C / methanol; ethyl acetate

With dmap; [bis(acetoxy)iodo]benzene; TEA; hydrogen; iodine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/S0960-894X(99)00038-4

Reference yield:

: 223270-80-2
2-[3-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-4-methyl-pentanoic acid

: (2R,5S,8S,11S)-11-Benzyl-2,5,8-triisobutyl-10,13-dimethyl-1,7-dioxa-4,10,13-triaza-cyclohexadecane-3,6,9,12,16-pentaone

Guidance literature:: Multi-step reaction with 4 steps

1: BOP-Cl, DIEA / 0 °C

2: TFA / -10 °C

3: H₂ / Pd/C / methanol; ethyl acetate

4: DPPA, DMAP / CH₂Cl₂ / 48 h

With dmap; diphenyl-phosphinic acid; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(99)00038-4

Reference yield:

: 223270-80-2
2-[3-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-4-methyl-pentanoic acid

: 223270-89-1
(S)-4-Methyl-2-[(R)-4-methyl-2-(3-methylamino-propionyloxy)-pentanoylamino]-pentanoic acid (S)-1-[((S)-1-carboxy-2-phenyl-ethyl)-methyl-carbamoyl]-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: BOP-Cl, DIEA / 0 °C

2: TFA / -10 °C

3: H₂ / Pd/C / methanol; ethyl acetate

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/S0960-894X(99)00038-4