(3R)-3-{[(1R)-1-{3-[(4-amino-3-chlorophenyl)carbonyl]-4-chloro-2-fluorophenyl}(2,2,3,3,3-deutero)propyl]amino}butanamide hydrochloride

Base Information

Chemical Name:(3R)-3-{[(1R)-1-{3-[(4-amino-3-chlorophenyl)carbonyl]-4-chloro-2-fluorophenyl}(2,2,3,3,3-deutero)propyl]amino}butanamide hydrochloride
CAS No.:1433392-60-9
Molecular Formula:C₂₀H₂₂Cl₂FN₃O₂*ClH
Molecular Weight:467.739
Hs Code.:

Synonyms:(3R)-3-{[(1R)-1-{3-[(4-amino-3-chlorophenyl)carbonyl]-4-chloro-2-fluorophenyl}(2,2,3,3,3-deutero)propyl]amino}butanamide hydrochloride

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Chemical Property of (3R)-3-{[(1R)-1-{3-[(4-amino-3-chlorophenyl)carbonyl]-4-chloro-2-fluorophenyl}(2,2,3,3,3-deutero)propyl]amino}butanamide hydrochloride

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Technology Process of (3R)-3-{[(1R)-1-{3-[(4-amino-3-chlorophenyl)carbonyl]-4-chloro-2-fluorophenyl}(2,2,3,3,3-deutero)propyl]amino}butanamide hydrochloride

There total 4 articles about (3R)-3-{[(1R)-1-{3-[(4-amino-3-chlorophenyl)carbonyl]-4-chloro-2-fluorophenyl}(2,2,3,3,3-deutero)propyl]amino}butanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433948-59-4
C₂₀H₁₇⁽²⁾H₅Cl₂FN₃O₂

: 1433392-60-9
(3R)-3-{[(1R)-1-{3-[(4-amino-3-chlorophenyl)carbonyl]-4-chloro-2-fluorophenyl}(2,2,3,3,3-deutero)propyl]amino}butanamide hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; ethyl acetate;

Reference yield:

: 1433381-31-7
(4-amino-3-chlorophenyl)[3-((R)-(1-amino-2,2,3,3,3-deutero)propyl)-6-chloro-2-fluorophenyl]methanone

: 1433392-60-9
(3R)-3-{[(1R)-1-{3-[(4-amino-3-chlorophenyl)carbonyl]-4-chloro-2-fluorophenyl}(2,2,3,3,3-deutero)propyl]amino}butanamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: lithium perchlorate / tetrahydrofuran / 18 h / 20 °C

2: ammonia / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

3: Chiralpak AD-H / Resolution of racemate

4: hydrogenchloride / dichloromethane; ethyl acetate

With hydrogenchloride; ammonia; lithium perchlorate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; ethyl acetate;

Reference yield:

: 1433408-58-2
C₃₀H₂₅⁽²⁾H₅Cl₂FN₃O₄

: 1433392-60-9
(3R)-3-{[(1R)-1-{3-[(4-amino-3-chlorophenyl)carbonyl]-4-chloro-2-fluorophenyl}(2,2,3,3,3-deutero)propyl]amino}butanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

2: Chiralpak AD-H / Resolution of racemate

3: hydrogenchloride / dichloromethane; ethyl acetate

With hydrogenchloride; ammonia; In 1-methyl-pyrrolidin-2-one; dichloromethane; ethyl acetate;