7-Chloro-2-cyclohexylmethyl-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Base Information

Chemical Name:7-Chloro-2-cyclohexylmethyl-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
CAS No.:146449-37-8
Molecular Formula:C₁₂H₁₃ClN₄O₃S
Molecular Weight:328.779
Hs Code.:

Synonyms:7-Chloro-2-cyclohexylmethyl-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Chemical Property of 7-Chloro-2-cyclohexylmethyl-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Technology Process of 7-Chloro-2-cyclohexylmethyl-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

There total 6 articles about 7-Chloro-2-cyclohexylmethyl-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

: 146449-24-3
2-Cyclohexylmethyl-7-hydroxy-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

: 146449-37-8
7-Chloro-2-cyclohexylmethyl-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: With tri-n-propylamine; trichlorophosphate; at 80 - 85 ℃; for 3h;
DOI:10.1248/cpb.40.2391

Reference yield:

: 4435-18-1,76293-17-9
2-cyclohexylideneacetonitrile

: 146449-37-8
7-Chloro-2-cyclohexylmethyl-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

2: 56.3 percent / CF₃COOH

3: 45.7 percent / heptane / 2 h / 140 - 150 °C

4: 81 percent / fuming HNO₃, AcOH / 2.5 h / Ambient temperature

5: 96.7 percent / tripropylamine, POCl₃ / 3 h / 80 - 85 °C

With tri-n-propylamine; hydrogen; nitric acid; acetic acid; trifluoroacetic acid; trichlorophosphate; palladium on activated charcoal; In ethanol; n-heptane;
DOI:10.1248/cpb.40.2391

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 146449-37-8
7-Chloro-2-cyclohexylmethyl-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 6 steps

1: 87.2 percent / 40percent aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 98 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

3: 56.3 percent / CF₃COOH

4: 45.7 percent / heptane / 2 h / 140 - 150 °C

5: 81 percent / fuming HNO₃, AcOH / 2.5 h / Ambient temperature

6: 96.7 percent / tripropylamine, POCl₃ / 3 h / 80 - 85 °C

With tri-n-propylamine; sodium hydroxide; hydrogen; nitric acid; acetic acid; trifluoroacetic acid; trichlorophosphate; palladium on activated charcoal; In ethanol; n-heptane; dichloromethane;
DOI:10.1248/cpb.40.2391