[3-(3-cyano-4-hydroxyphenyl)-propyl]carbamic acid 2-trimethylsilyle 2-trimethylsilylethyl ester

Base Information

Chemical Name:[3-(3-cyano-4-hydroxyphenyl)-propyl]carbamic acid 2-trimethylsilyle 2-trimethylsilylethyl ester
CAS No.:883455-50-3
Molecular Formula:C₁₆H₂₄N₂O₃Si
Molecular Weight:320.464
Hs Code.:

Synonyms:[3-(3-cyano-4-hydroxyphenyl)-propyl]carbamic acid 2-trimethylsilyle 2-trimethylsilylethyl ester

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Chemical Property of [3-(3-cyano-4-hydroxyphenyl)-propyl]carbamic acid 2-trimethylsilyle 2-trimethylsilylethyl ester

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Technology Process of [3-(3-cyano-4-hydroxyphenyl)-propyl]carbamic acid 2-trimethylsilyle 2-trimethylsilylethyl ester

There total 5 articles about [3-(3-cyano-4-hydroxyphenyl)-propyl]carbamic acid 2-trimethylsilyle 2-trimethylsilylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 883455-49-0
[3-(3-cyano-4-hydroxyphenyl)-prop-2-ynyl]carbamic acid 2-trimethylsilylethyl ester

: 883455-50-3
[3-(3-cyano-4-hydroxyphenyl)-propyl]carbamic acid 2-trimethylsilyle 2-trimethylsilylethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1016/j.tet.2005.12.012

Reference yield:

: 685103-95-1
2-hydroxy-5-iodobenzonitrile

: 883455-50-3
[3-(3-cyano-4-hydroxyphenyl)-propyl]carbamic acid 2-trimethylsilyle 2-trimethylsilylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / ethyldiisopropylamine; copper(I) iodide / Pd(PPh₃)4 / dimethylformamide / 0 - 20 °C

2: 90 percent / hydrogen / palladium on charcoal / ethanol

With copper(l) iodide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1016/j.tet.2005.12.012

Reference yield:

: p-nitrophenyl-2-trimethylsilylethyl-carbonate

: 883455-50-3
[3-(3-cyano-4-hydroxyphenyl)-propyl]carbamic acid 2-trimethylsilyle 2-trimethylsilylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / ethyldiisopropylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h / Heating

2: 95 percent / ethyldiisopropylamine; copper(I) iodide / Pd(PPh₃)4 / dimethylformamide / 0 - 20 °C

3: 90 percent / hydrogen / palladium on charcoal / ethanol

With dmap; copper(l) iodide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1016/j.tet.2005.12.012