Carbonic acid (2R,3R,4R)-4-(2-benzyloxy-ethyl)-2-hydroxymethyl-5-oxo-pyrrolidin-3-ylmethyl ester ethyl ester

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Chemical Name:Carbonic acid (2R,3R,4R)-4-(2-benzyloxy-ethyl)-2-hydroxymethyl-5-oxo-pyrrolidin-3-ylmethyl ester ethyl ester
CAS No.:856682-02-5
Molecular Formula:C₁₈H₂₅NO₆
Molecular Weight:351.4
Hs Code.:

Synonyms:Carbonic acid (2R,3R,4R)-4-(2-benzyloxy-ethyl)-2-hydroxymethyl-5-oxo-pyrrolidin-3-ylmethyl ester ethyl ester

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Chemical Property of Carbonic acid (2R,3R,4R)-4-(2-benzyloxy-ethyl)-2-hydroxymethyl-5-oxo-pyrrolidin-3-ylmethyl ester ethyl ester

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Technology Process of Carbonic acid (2R,3R,4R)-4-(2-benzyloxy-ethyl)-2-hydroxymethyl-5-oxo-pyrrolidin-3-ylmethyl ester ethyl ester

There total 6 articles about Carbonic acid (2R,3R,4R)-4-(2-benzyloxy-ethyl)-2-hydroxymethyl-5-oxo-pyrrolidin-3-ylmethyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 856682-10-5
Carbonic acid (3S,6R,7R,7aR)-6-(2-benzyloxy-ethyl)-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-7-ylmethyl ester ethyl ester

: 856682-02-5
Carbonic acid (2R,3R,4R)-4-(2-benzyloxy-ethyl)-2-hydroxymethyl-5-oxo-pyrrolidin-3-ylmethyl ester ethyl ester

Guidance literature:: With trifluorormethanesulfonic acid; In tetrahydrofuran; water; at 20 ℃; for 18h;
DOI:10.1021/ja0522783

Reference yield:

: 856681-99-7
(3S,7S,7aR)-3-Phenyl-7-vinyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

: 856682-02-5
Carbonic acid (2R,3R,4R)-4-(2-benzyloxy-ethyl)-2-hydroxymethyl-5-oxo-pyrrolidin-3-ylmethyl ester ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / 0 °C

1.2: 77 percent / tetrahydrofuran; hexane / 0 - 20 °C

2.1: O₃ / CH₂Cl₂; methanol / -78 °C

2.2: 86 percent / NaBH₄ / tetrahydrofuran; methanol / -78 - 0 °C

3.1: 96 percent / pyridine / 0 - 20 °C

4.1: 100 percent / TfOH / tetrahydrofuran; H₂O / 18 h / 20 °C

With trifluorormethanesulfonic acid; ozone; lithium diisopropyl amide; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; water;
DOI:10.1021/ja0522783

Reference yield:

: 856682-00-3
(3S,6R,7R,7aR)-6-(2-Benzyloxy-ethyl)-3-phenyl-7-vinyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

: 856682-02-5
Carbonic acid (2R,3R,4R)-4-(2-benzyloxy-ethyl)-2-hydroxymethyl-5-oxo-pyrrolidin-3-ylmethyl ester ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: O₃ / CH₂Cl₂; methanol / -78 °C

1.2: 86 percent / NaBH₄ / tetrahydrofuran; methanol / -78 - 0 °C

2.1: 96 percent / pyridine / 0 - 20 °C

3.1: 100 percent / TfOH / tetrahydrofuran; H₂O / 18 h / 20 °C

With trifluorormethanesulfonic acid; ozone; In tetrahydrofuran; pyridine; methanol; dichloromethane; water;
DOI:10.1021/ja0522783