N-[3-(Quinolin-2-ylmethoxy)-phenyl]-malonamic acid methyl ester

Base Information

• Chemical Name: N-[3-(Quinolin-2-ylmethoxy)-phenyl]-malonamic acid methyl ester
• CAS No.: 102650-01-1
• Molecular Formula: C₂₀H₁₈N₂O₄
• Molecular Weight: 350.374
• Mol file: 102650-01-1.mol

Synonyms:N-[3-(Quinolin-2-ylmethoxy)-phenyl]-malonamic acid methyl ester

Chemical Property of N-[3-(Quinolin-2-ylmethoxy)-phenyl]-malonamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-(Quinolin-2-ylmethoxy)-phenyl]-malonamic acid methyl ester

There total 4 articles about N-[3-(Quinolin-2-ylmethoxy)-phenyl]-malonamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) + 3-[(2-quinolinyl)methoxy]benzenamine (105326-65-6) → N-[3-(Quinolin-2-ylmethoxy)-phenyl]-malonamic acid methyl ester (102650-01-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jm00158a019

Reference yield:

2-Chloromethylquinoline (4377-41-7) → N-[3-(Quinolin-2-ylmethoxy)-phenyl]-malonamic acid methyl ester (102650-01-1)

Guidance literature:

Multi-step reaction with 3 steps

1: cesium carbonate, sodium carbonate, potassium iodide / acetone / 72 h / Heating

2: hydrochloric acid, iron / ethanol / Ambient temperature

3: 71 percent / triethylamine / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; iron; sodium carbonate; caesium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; ethanol; acetone;

DOI:10.1021/jm00158a019

Reference yield:

meta-nitrophenol (554-84-7) → N-[3-(Quinolin-2-ylmethoxy)-phenyl]-malonamic acid methyl ester (102650-01-1)

Guidance literature:

Multi-step reaction with 3 steps

1: cesium carbonate, sodium carbonate, potassium iodide / acetone / 72 h / Heating

2: hydrochloric acid, iron / ethanol / Ambient temperature

3: 71 percent / triethylamine / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; iron; sodium carbonate; caesium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; ethanol; acetone;

DOI:10.1021/jm00158a019

upstream raw materials:

3-chloro-3-oxopropanoic acid methyl ester

3-[(2-quinolinyl)methoxy]benzenamine

2-Chloromethylquinoline

meta-nitrophenol