2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)acetaldehyde

Base Information

Chemical Name:2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)acetaldehyde
CAS No.:953786-52-2
Molecular Formula:C₁₇H₁₇IO₄
Molecular Weight:412.224
Hs Code.:

Synonyms:2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)acetaldehyde

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Chemical Property of 2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)acetaldehyde

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Technology Process of 2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)acetaldehyde

There total 1 articles about 2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 909766-98-9
4-benzyloxy-6-iodo-2,3-dimethoxybenzaldehyde

: 953786-52-2
2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)acetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: KOt-Bu / tetrahydrofuran / 0 - 20 °C

1.2: tetrahydrofuran / 16 h / 20 °C

2.1: 423 mg / aq. HCl / acetone / 12 h / Heating

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; acetone; 1.2: Wittig reaction;
DOI:10.1021/ol701757f

Reference yield:

: 953786-52-2
2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)acetaldehyde

: C₁₇H₁₇O₅I

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃;
DOI:10.1021/ol701757f

Reference yield:

: 953786-52-2
2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)acetaldehyde

: 953786-60-2
(S)-2-(4-(benzyloxy)-6-iodo-2,3-dimethoxyphenyl)-1-((3R,5S)-5-tert-butyldimethylsilyloxy-3-(triethylsilyloxy)cyclopent-1-enyl)-1-chloroethane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2-methyl-2-butene; NaH₂PO₄; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 20 °C

2.1: triethylamine; pivaloyl chloride / CH₂Cl₂ / 0 °C

2.2: 31.8 mg / triethylamine / CH₂Cl₂ / 2 h / 0 °C

3.1: i-PrMgCl*LiCl; 15-crown-5 / tetrahydrofuran / -20 - 20 °C

3.2: 63 percent / tetrahydrofuran / 7 h / -20 - 0 °C

4.1: BH₃*THF complex / (R)-Corey-Bakshi-Shibata catalyst / tetrahydrofuran / 3 h / 10 °C

5.1: 65 percent / triethylamine; methanesulfonyl chloride / CH₂Cl₂ / -25 - 0 °C

With sodium chlorite; sodium dihydrogenphosphate; TurboGrignard; borane-THF; 2-methyl-but-2-ene; 15-crown-5; pivaloyl chloride; methanesulfonyl chloride; triethylamine; (R)-Corey-Bakshi-Shibata catalyst; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol701757f