(S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol

Base Information

Chemical Name:(S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol
CAS No.:239807-73-9
Molecular Formula:C₂₃H₃₃N₃O₂
Molecular Weight:383.534
Hs Code.:

Synonyms:(S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol

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Chemical Property of (S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol

Chemical Property:

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Technology Process of (S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol

There total 4 articles about (S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 239807-72-8
[(2R)-2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-(phenylmethyl)carbamic acid, 1,1-dimethylethyl ester

: 239807-73-9
(S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 22h;
DOI:10.1002/jhet.5570380433

Reference yield:

: 100-46-9
benzylamine

: 239807-73-9
(S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / hexane / 62 h / 20 °C

2.1: 84 percent / Et₃N / tetrahydrofuran / 20 h / 0 - 20 °C

3.1: KOH / methanol / 0.33 h / 20 °C

3.2: 63 percent / methanol / 20 h / 0 - 20 °C

4.1: TFA / CH₂Cl₂ / 22 h / 20 °C

With potassium hydroxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1002/jhet.5570380433

Reference yield:

: 198755-87-2,278788-93-5
(2S)-1-chloro-3-[(phenylmethyl)amino]-2-propanol

: 239807-73-9
(S)-1-Benzylamino-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / Et₃N / tetrahydrofuran / 20 h / 0 - 20 °C

2.1: KOH / methanol / 0.33 h / 20 °C

2.2: 63 percent / methanol / 20 h / 0 - 20 °C

3.1: TFA / CH₂Cl₂ / 22 h / 20 °C

With potassium hydroxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/jhet.5570380433