Technology Process of 9-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-nonanoic acid phenethyl-amide
There total 4 articles about 9-(6,6-dimethyl-4,8-dioxa-spiro[2.5]oct-1-en-1-yl)-nonanoic acid phenethyl-amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-BuLi; HMPA / tetrahydrofuran / 0.97 h / -78 °C
1.2: 62 percent / tetrahydrofuran / 7.5 h / -23 °C
2.1: 96 percent / tetra-n-butylammonium fluoride; AcOH / tetrahydrofuran / 14 h / 0 - 20 °C
3.1: NaHCO3; KBr; 2,2,6,6-tetramethylpiperidinyl-1-oxyl / Aliquat 336; NaOCl / CH2Cl2; H2O / 0.5 h / 0 °C
4.1: 1,1-carbonyldiimidazole / CH2Cl2 / 0.5 h / 0 °C
4.2: CH2Cl2 / 2 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; acetic acid; 1,1'-carbonyldiimidazole; potassium bromide;
sodium hypochlorite; Aliquat 336;
In
tetrahydrofuran; dichloromethane; water;
1.1: Metallation / 1.2: Alkylation / 2.1: desilylation / 3.1: Oxidation / 4.1: Addition / 4.2: Addition;
DOI:10.1021/ja992355s
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NaHCO3; KBr; 2,2,6,6-tetramethylpiperidinyl-1-oxyl / Aliquat 336; NaOCl / CH2Cl2; H2O / 0.5 h / 0 °C
2.1: 1,1-carbonyldiimidazole / CH2Cl2 / 0.5 h / 0 °C
2.2: CH2Cl2 / 2 h
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; potassium bromide;
sodium hypochlorite; Aliquat 336;
In
dichloromethane; water;
1.1: Oxidation / 2.1: Addition / 2.2: Addition;
DOI:10.1021/ja992355s
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 96 percent / tetra-n-butylammonium fluoride; AcOH / tetrahydrofuran / 14 h / 0 - 20 °C
2.1: NaHCO3; KBr; 2,2,6,6-tetramethylpiperidinyl-1-oxyl / Aliquat 336; NaOCl / CH2Cl2; H2O / 0.5 h / 0 °C
3.1: 1,1-carbonyldiimidazole / CH2Cl2 / 0.5 h / 0 °C
3.2: CH2Cl2 / 2 h
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; acetic acid; 1,1'-carbonyldiimidazole; potassium bromide;
sodium hypochlorite; Aliquat 336;
In
tetrahydrofuran; dichloromethane; water;
1.1: desilylation / 2.1: Oxidation / 3.1: Addition / 3.2: Addition;
DOI:10.1021/ja992355s
