3-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]pentane-1,3,5-triol

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Chemical Name:3-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]pentane-1,3,5-triol
CAS No.:1312482-17-9
Molecular Formula:C₁₉H₁₉F₃N₄O₃S
Molecular Weight:440.446
Hs Code.:

Synonyms:3-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]pentane-1,3,5-triol

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Chemical Property of 3-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]pentane-1,3,5-triol

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Technology Process of 3-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]pentane-1,3,5-triol

There total 3 articles about 3-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]pentane-1,3,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.8%

: 1312536-77-8
2,2,3,3,11,11,12,12-octamethyl-7-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-4,10-dioxa-3,11-disilatridecan-7-ol

: 1312482-17-9
3-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]pentane-1,3,5-triol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 4254-85-7
1,5-dihydroxypentan-3-one

: 1312482-17-9
3-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]pentane-1,3,5-triol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1312536-76-7
2,2,3,3,11,11,12,12-octamethyl-4,10-dioxa-3,11-disilatridecan-7-one

: 1312482-17-9
3-[5-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]pentane-1,3,5-triol

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With tetrabutyl ammonium fluoride; lithium diisopropyl amide; In tetrahydrofuran;