N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin

Base Information

• Chemical Name: N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin
• CAS No.: 101376-32-3
• Molecular Formula: C₅₅H₅₈N₂O₂₁
• Molecular Weight: 1083.07
• Mol file: 101376-32-3.mol

Synonyms:N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin

Chemical Property of N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin

There total 4 articles about N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-benzylester (100929-05-3) → N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin (101376-32-3)

Guidance literature:

With formic acid; palladium on activated charcoal; In methanol; for 0.2h;

Reference yield:

N-(fluoren-9-ylmethoxycarbonyl)-L-threonine benzyl ester (73724-48-8) → N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin (101376-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) mol. sieve, 4 Angstroem 2.) AgClO₄ / 1.) CH₂Cl₂, toluene, -20 deg C, 1 h 2.) CH₂Cl₂, toluene, 20 h

2: 1.) H₂S / 1.) pyridine, H₂O, 20 h, RT 2.) 3 h

3: 85 percent / 85percent HCO₂H / Pd/C / methanol / 0.2 h

With formic acid; molecular sieve; 4 A molecular sieve; hydrogen sulfide; silver perchlorate; palladium on activated charcoal; In methanol;

Reference yield:

2-azido-4,6-di-O-benzoyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranosyl bromide (87376-57-6) → N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin (101376-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) mol. sieve, 4 Angstroem 2.) AgClO₄ / 1.) CH₂Cl₂, toluene, -20 deg C, 1 h 2.) CH₂Cl₂, toluene, 20 h

2: 1.) H₂S / 1.) pyridine, H₂O, 20 h, RT 2.) 3 h

3: 85 percent / 85percent HCO₂H / Pd/C / methanol / 0.2 h

With formic acid; molecular sieve; 4 A molecular sieve; hydrogen sulfide; silver perchlorate; palladium on activated charcoal; In methanol;

upstream raw materials:

N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-benzylester

N-(fluoren-9-ylmethoxycarbonyl)-L-threonine benzyl ester

2-azido-4,6-di-O-benzoyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranosyl bromide

N-(9-Fluorenylmethoxycarbonyl)-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-azido-4,6-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-benzylester

Downstream raw materials:

C₁₅₇H₁₈₀N₈O₇₃