1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

Base Information

• Chemical Name: 1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride
• CAS No.: 1089210-02-5
• Molecular Formula: C₂₈H₃₃F₃N₂O₄S*ClH
• Molecular Weight: 587.103
• Mol file: 1089210-02-5.mol

Synonyms:1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

Chemical Property of 1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride

There total 6 articles about 1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane (1089758-82-6) → 1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride (1089210-02-5)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

7-acetoxy-2,3-dihydro-2,2-dimethyl-benzofuran-5-sulfonyl chloride (1089210-09-2) → 1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride (1089210-02-5)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 2 h / 0 - 5 °C

2: potassium hydroxide / ethanol / 2 h / 20 °C

3: sodium carbonate / 5 h / 140 °C

4: hydrogenchloride / water; ethyl acetate

With hydrogenchloride; potassium hydroxide; sodium carbonate; In ethanol; water; ethyl acetate;

Reference yield:

7-acetoxy-2,3-dihydro-2,2-dimethyl-benzofuran-5-sulfonic acid N-cyclopropyl-amide (1089210-13-8) → 1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane hydrochloride (1089210-02-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 2 h / 20 °C

2: sodium carbonate / 5 h / 140 °C

3: hydrogenchloride / water; ethyl acetate

With hydrogenchloride; potassium hydroxide; sodium carbonate; In ethanol; water; ethyl acetate;

upstream raw materials:

1-{[5-(N-cyclopropyl-sulfamoyl)-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl]-oxy}-3-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-propane

4-(3-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine

N-cyclopropyl-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofurane-5-sulfonamide

7-acetoxy-2,3-dihydro-2,2-dimethyl-benzofuran-5-sulfonyl chloride