(R)-3-(4-isopropylphenyl)-N-(1-methoxypropan-2-yl)-7-methylpyrazolo[1,5-a]pyrimidine-6-

Base Information

Chemical Name:(R)-3-(4-isopropylphenyl)-N-(1-methoxypropan-2-yl)-7-methylpyrazolo[1,5-a]pyrimidine-6-
CAS No.:1370287-54-9
Molecular Formula:C₂₁H₂₆N₄O₂
Molecular Weight:366.463
Hs Code.:

Synonyms:(R)-3-(4-isopropylphenyl)-N-(1-methoxypropan-2-yl)-7-methylpyrazolo[1,5-a]pyrimidine-6-

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Chemical Property of (R)-3-(4-isopropylphenyl)-N-(1-methoxypropan-2-yl)-7-methylpyrazolo[1,5-a]pyrimidine-6-

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Technology Process of (R)-3-(4-isopropylphenyl)-N-(1-methoxypropan-2-yl)-7-methylpyrazolo[1,5-a]pyrimidine-6-

There total 3 articles about (R)-3-(4-isopropylphenyl)-N-(1-methoxypropan-2-yl)-7-methylpyrazolo[1,5-a]pyrimidine-6- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 626220-76-6
(2R)-(-)1-methoxypropan-2-amine hydrochloride

: 941573-59-7
3-(4-isopropylphenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid

: 1370287-54-9
(R)-3-(4-isopropylphenyl)-N-(1-methoxypropan-2-yl)-7-methylpyrazolo[1,5-a]pyrimidine-6-

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm300164q

Reference yield:

: 941573-53-1
ethyl 3-(4-isopropylphenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

: 1370287-54-9
(R)-3-(4-isopropylphenyl)-N-(1-methoxypropan-2-yl)-7-methylpyrazolo[1,5-a]pyrimidine-6-

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; methanol; water / 16 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm300164q

Reference yield:

: 3788-94-1
2-ethoxymethylene-3-oxobutanoic acid ethyl ester

: 1370287-54-9
(R)-3-(4-isopropylphenyl)-N-(1-methoxypropan-2-yl)-7-methylpyrazolo[1,5-a]pyrimidine-6-

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 3 h / Reflux

2: lithium hydroxide / tetrahydrofuran; methanol; water / 16 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm300164q