(R)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide

Base Information

• Chemical Name: (R)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide
• CAS No.: 241477-22-5
• Molecular Formula: C₂₆H₃₅N₃O₈
• Molecular Weight: 517.579

Synonyms:(R)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide

Chemical Property of (R)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide

There total 16 articles about (R)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-2-[2-(4-heptyloxyphenyl)ethyl]butane-1,4-diol (177259-00-6) + 3,5-dinitrobenoyl chloride (99-33-2) → (S)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide (241477-21-4) + (R)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide (241477-22-5)

Guidance literature:

With potassium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 0.25h;

DOI:10.1021/jm000173z

Reference yield:

1-Bromoheptane (629-04-9) → (R)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide (241477-22-5)

Guidance literature:

Multi-step reaction with 15 steps

1.1: 94 percent / NaOEt / ethanol / 7 h / Heating

2.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

3.1: NaI / butan-2-one / 2 h / Heating

4.1: NaH / dimethylformamide / 0.5 h

4.2: 86 percent / dimethylformamide / 3 h

5.1: 86 percent / 1 N aq. HCl / methanol / 5 h

6.1: 100 percent / 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C

7.1: Et₃N / tetrahydrofuran / 0.25 h / -5 °C

8.1: aq. NaN₃ / tetrahydrofuran / 1 h / 0 °C

9.1: benzene / 1 h / Heating

10.1: benzene / 7 h / Heating

11.1: LiBH₄ / tetrahydrofuran / 0.5 h / Heating

12.1: pyridine / 13 h / 20 °C

13.1: Me₃SiI / CH₂Cl₂ / 7 h

13.2: 70 percent / pyridine / 13 h

14.1: 93 percent / 2 M aq. LiOH / tetrahydrofuran; methanol / 2 h / Heating

15.1: aq. KHCO₃ / ethyl acetate / 0.25 h / 20 °C

With pyridine; hydrogenchloride; lithium hydroxide; sodium hydroxide; lithium borohydride; sodium azide; trimethylsilyl iodide; sodium ethanolate; sodium hydride; potassium hydrogencarbonate; triethylamine; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; butanone; benzene; 1.1: Alkylation / 2.1: mesylation / 3.1: Iodination / 4.1: Metallation / 4.2: Alkylation / 5.1: Cyclization / 6.1: Hydrolysis / 7.1: Acylation / 8.1: Substitution / 9.1: Curtius rearrangement / 10.1: Addition / 11.1: Reduction / 12.1: Acetylation / 13.1: demethoxycarbonylation / 13.2: Acetylation / 14.1: Hydrolysis / 15.1: Acylation;

DOI:10.1021/jm000173z

Reference yield:

p-hydroxyphenethyl alcohol (501-94-0) → (R)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide (241477-22-5)

Guidance literature:

Multi-step reaction with 15 steps

1.1: 94 percent / NaOEt / ethanol / 7 h / Heating

2.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

3.1: NaI / butan-2-one / 2 h / Heating

4.1: NaH / dimethylformamide / 0.5 h

4.2: 86 percent / dimethylformamide / 3 h

5.1: 86 percent / 1 N aq. HCl / methanol / 5 h

6.1: 100 percent / 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C

7.1: Et₃N / tetrahydrofuran / 0.25 h / -5 °C

8.1: aq. NaN₃ / tetrahydrofuran / 1 h / 0 °C

9.1: benzene / 1 h / Heating

10.1: benzene / 7 h / Heating

11.1: LiBH₄ / tetrahydrofuran / 0.5 h / Heating

12.1: pyridine / 13 h / 20 °C

13.1: Me₃SiI / CH₂Cl₂ / 7 h

13.2: 70 percent / pyridine / 13 h

14.1: 93 percent / 2 M aq. LiOH / tetrahydrofuran; methanol / 2 h / Heating

15.1: aq. KHCO₃ / ethyl acetate / 0.25 h / 20 °C

With pyridine; hydrogenchloride; lithium hydroxide; sodium hydroxide; lithium borohydride; sodium azide; trimethylsilyl iodide; sodium ethanolate; sodium hydride; potassium hydrogencarbonate; triethylamine; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; butanone; benzene; 1.1: Alkylation / 2.1: mesylation / 3.1: Iodination / 4.1: Metallation / 4.2: Alkylation / 5.1: Cyclization / 6.1: Hydrolysis / 7.1: Acylation / 8.1: Substitution / 9.1: Curtius rearrangement / 10.1: Addition / 11.1: Reduction / 12.1: Acetylation / 13.1: demethoxycarbonylation / 13.2: Acetylation / 14.1: Hydrolysis / 15.1: Acylation;

DOI:10.1021/jm000173z

upstream raw materials:

2-amino-2-[2-(4-heptyloxyphenyl)ethyl]butane-1,4-diol

3,5-dinitrobenoyl chloride

1-Bromoheptane

p-hydroxyphenethyl alcohol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 241477-22-5 (R)-3,5-dinitro-N-[1-[2-(4-heptyloxyphenyl)ethyl]-3-hydroxy-1-hydroxymethylpropyl]benzamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send