N-(1-(4-(tert-butyl)phenyl)-2-chloroethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide

Base Information

• Chemical Name: N-(1-(4-(tert-butyl)phenyl)-2-chloroethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide
• CAS No.: 1359764-31-0
• Molecular Formula: C₁₉H₂₅Cl₂N₃O
• Molecular Weight: 382.333

Synonyms:N-(1-(4-(tert-butyl)phenyl)-2-chloroethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide

Chemical Property of N-(1-(4-(tert-butyl)phenyl)-2-chloroethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide

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Technology Process of N-(1-(4-(tert-butyl)phenyl)-2-chloroethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide

There total 10 articles about N-(1-(4-(tert-butyl)phenyl)-2-chloroethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-(1-(4-(tert-butyl)phenyl)-2-hydroxyethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide (1359764-21-8) → N-(1-(4-(tert-butyl)phenyl)-2-chloroethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide (1359764-31-0)

Guidance literature:

With thionyl chloride; In toluene; at 80 ℃; for 3h;

DOI:10.1021/jf204778v

Reference yield:

4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid → N-(1-(4-(tert-butyl)phenyl)-2-chloroethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide (1359764-31-0)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 1 h / Reflux

2: triethylamine / toluene / 8 h / -5 °C

3: thionyl chloride / toluene / 3 h / 80 °C

With thionyl chloride; triethylamine; In toluene;

DOI:10.1021/jf204778v

Reference yield:

4-chloro-5-ethyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester → N-(1-(4-(tert-butyl)phenyl)-2-chloroethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide (1359764-31-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol / 3 h / Reflux

1.2: pH 2

2.1: thionyl chloride / 1 h / Reflux

3.1: triethylamine / toluene / 8 h / -5 °C

4.1: thionyl chloride / toluene / 3 h / 80 °C

With thionyl chloride; triethylamine; sodium hydroxide; In ethanol; toluene;

DOI:10.1021/jf204778v

upstream raw materials:

1-methyl-3-ethyl-4-chloro-1H-pyrazol-5-ylformylic acid chloride

3-ethyl-1-methylpyrazole-5-carboxylic acid ethyl ester

N-(1-(4-(tert-butyl)phenyl)-2-hydroxyethyl)-4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide

ethyl 2-(4-(tert-butyl)phenyl)-2-(hydroxyimino)acetate

Downstream raw materials:

4-(4-(tert-butyl)phenyl)-2-(4-chloro-3-ethyl-1-methyl-1H-pyrazol-5-yl)-4,5-dihydrooxazole

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