methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate

Base Information

Chemical Name:methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate
CAS No.:1265400-31-4
Molecular Formula:C₂₃H₃₁N₃O₃
Molecular Weight:397.517
Hs Code.:

Synonyms:methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate

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Chemical Property of methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate

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Technology Process of methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate

There total 7 articles about methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1265400-26-7
methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate

: 6482-24-2
2-Bromoethyl methyl ether

: 1265400-31-4
methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate

Guidance literature:: methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 ℃; for 0.25h;

2-Bromoethyl methyl ether; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 - 20 ℃; for 3h;

Reference yield:

: 162498-52-4
(2,4-dichloro-6-methylpyrimidin-5-yl)acetic acid methyl ester

: 1265400-31-4
methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

2.1: tetrahydrofuran / 1 h / 110 °C / Sealed tube; Microwave irradiation

3.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -15 °C

3.2: 3 h / -15 - 20 °C

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 10420-33-4
dimethyl 2-acetylsuccinate

: 1265400-31-4
methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 18 h / Reflux

1.2: 0 °C

2.1: water; chloroacetic acid / 24 h / Reflux

3.1: thionyl chloride / 12 h / 0 °C / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 115 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

6.1: tetrahydrofuran / 1 h / 110 °C / Sealed tube; Microwave irradiation

7.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -15 °C

7.2: 3 h / -15 - 20 °C

With thionyl chloride; water; sodium methylate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; chloroacetic acid; lithium hexamethyldisilazane; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;