2-(bis(2-methylphenyl)methyl)-2-methyl-1H-indene-1,3(2H)-dione

Base Information

• Chemical Name: 2-(bis(2-methylphenyl)methyl)-2-methyl-1H-indene-1,3(2H)-dione
• CAS No.: 1356835-88-5
• Molecular Formula: C₂₅H₂₂O₂
• Molecular Weight: 354.448
• Mol file: 1356835-88-5.mol

Synonyms:2-(bis(2-methylphenyl)methyl)-2-methyl-1H-indene-1,3(2H)-dione

Chemical Property of 2-(bis(2-methylphenyl)methyl)-2-methyl-1H-indene-1,3(2H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(bis(2-methylphenyl)methyl)-2-methyl-1H-indene-1,3(2H)-dione

There total 4 articles about 2-(bis(2-methylphenyl)methyl)-2-methyl-1H-indene-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methyl-indan-1,3-dione (876-83-5) + bis(2-methylphenyl)methanol (2845-91-2) → 2-(bis(2-methylphenyl)methyl)-2-methyl-1H-indene-1,3(2H)-dione (1356835-88-5)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; at 110 ℃; for 17h;

DOI:10.1039/c1cc14703j

Reference yield:

2-methylphenyl bromide (95-46-5) → 2-(bis(2-methylphenyl)methyl)-2-methyl-1H-indene-1,3(2H)-dione (1356835-88-5)

Guidance literature:

Multi-step reaction with 3 steps

1: magnesium / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate; sodium hydrogensulfate monohydrate / acetonitrile / 26 h / Reflux

3: toluene-4-sulfonic acid / benzene / 17 h / 110 °C

With sodium tetrahydroborate; sodium hydrogensulfate monohydrate; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; acetonitrile; benzene;

DOI:10.1039/c1cc14703j

Reference yield:

Diethyl phthalate (84-66-2) → 2-(bis(2-methylphenyl)methyl)-2-methyl-1H-indene-1,3(2H)-dione (1356835-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; benzene / 72 h / 20 °C / Reflux; Inert atmosphere

2: toluene-4-sulfonic acid / benzene / 17 h / 110 °C

With sodium hydride; toluene-4-sulfonic acid; In mineral oil; benzene;

DOI:10.1039/c1cc14703j

upstream raw materials:

2-methyl-indan-1,3-dione

bis(2-methylphenyl)methanol

2-methylphenyl bromide

Diethyl phthalate

Downstream raw materials:

C₂₅H₂₆O₂