1-(3',4'-dimethoxybenzyl)-3-phenyl-4-[4-(methylsulfonyl)phenyl]-1H-pyrrol-2(5H)-one

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Chemical Name:1-(3',4'-dimethoxybenzyl)-3-phenyl-4-[4-(methylsulfonyl)phenyl]-1H-pyrrol-2(5H)-one
CAS No.:952340-24-8
Molecular Formula:C₂₆H₂₅NO₅S
Molecular Weight:463.554
Hs Code.:

Synonyms:1-(3',4'-dimethoxybenzyl)-3-phenyl-4-[4-(methylsulfonyl)phenyl]-1H-pyrrol-2(5H)-one

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Chemical Property of 1-(3',4'-dimethoxybenzyl)-3-phenyl-4-[4-(methylsulfonyl)phenyl]-1H-pyrrol-2(5H)-one

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Technology Process of 1-(3',4'-dimethoxybenzyl)-3-phenyl-4-[4-(methylsulfonyl)phenyl]-1H-pyrrol-2(5H)-one

There total 7 articles about 1-(3',4'-dimethoxybenzyl)-3-phenyl-4-[4-(methylsulfonyl)phenyl]-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 952340-21-5
1-(3',4'-dimethoxybenzyl)-4-[4''-(methylthio)phenyl]-3-phenyl-4-1H-pyrrol-2(5H)-one

: 952340-24-8
1-(3',4'-dimethoxybenzyl)-3-phenyl-4-[4-(methylsulfonyl)phenyl]-1H-pyrrol-2(5H)-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1055/s-2007-983778

Reference yield:

: 952340-14-6
ethyl 2-[N-(3',4'-dimethoxybenzyl)-2''-phenylacetamido]acetate

: 952340-24-8
1-(3',4'-dimethoxybenzyl)-3-phenyl-4-[4-(methylsulfonyl)phenyl]-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 5.36 g / t-BuONa / tetrahydrofuran / 6 h / 0 - 20 °C

2: 95 percent / Et₃N / CH₂Cl₂ / 1 h / -15 °C

3: 89 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / Heating

4: 81 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 2 h / 20 °C

With sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium t-butanolate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; 1: Dieckmann-type cyclocondensation / 3: Suzuki-Miyaura reaction;
DOI:10.1055/s-2007-983778

Reference yield:

: 952340-15-7
1-(3',4'-dimethoxybenzyl)-4-hydroxy-3-phenyl-1H-pyrrol-2(5H)-one

: 952340-24-8
1-(3',4'-dimethoxybenzyl)-3-phenyl-4-[4-(methylsulfonyl)phenyl]-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 1 h / -15 °C

2: 89 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / Heating

3: 81 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 2 h / 20 °C

With sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; 2: Suzuki-Miyaura reaction;
DOI:10.1055/s-2007-983778