Technology Process of 8-Oxo-5-p-tolyl-8H-pyrano[3,4-b]pyridine-6-carbonyl chloride
There total 3 articles about 8-Oxo-5-p-tolyl-8H-pyrano[3,4-b]pyridine-6-carbonyl chloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride, DMF / tetrahydrofuran / 2 h / Heating
2: NaH / tetrahydrofuran / 0.5 h / -10 °C
3: 85 percent / AcOH, conc. HCl / 3 h / Heating
4: thionyl chloride, DMF / 1,2-dichloro-ethane; tetrahydrofuran / 1.5 h / Heating
With
hydrogenchloride; thionyl chloride; sodium hydride; acetic acid; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1,2-dichloro-ethane;
1: Chlorination / 2: cyclocondensation / 3: Decarboxylation / 4: Chlorination;
DOI:10.1021/jm990220r
- Guidance literature:
-
Multi-step reaction with 3 steps
1: NaH / tetrahydrofuran / 0.5 h / -10 °C
2: 85 percent / AcOH, conc. HCl / 3 h / Heating
3: thionyl chloride, DMF / 1,2-dichloro-ethane; tetrahydrofuran / 1.5 h / Heating
With
hydrogenchloride; thionyl chloride; sodium hydride; acetic acid; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1,2-dichloro-ethane;
1: cyclocondensation / 2: Decarboxylation / 3: Chlorination;
DOI:10.1021/jm990220r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 85 percent / AcOH, conc. HCl / 3 h / Heating
2: thionyl chloride, DMF / 1,2-dichloro-ethane; tetrahydrofuran / 1.5 h / Heating
With
hydrogenchloride; thionyl chloride; acetic acid; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1,2-dichloro-ethane;
1: Decarboxylation / 2: Chlorination;
DOI:10.1021/jm990220r
