(R,Z)-2-(3-((4-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzamido)pentanedioic acid

Base Information

Chemical Name:(R,Z)-2-(3-((4-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzamido)pentanedioic acid
CAS No.:1384338-89-9
Molecular Formula:C₂₃H₂₁N₃O₆S₂
Molecular Weight:499.568
Hs Code.:

Synonyms:(R,Z)-2-(3-((4-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzamido)pentanedioic acid

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Chemical Property of (R,Z)-2-(3-((4-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzamido)pentanedioic acid

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Technology Process of (R,Z)-2-(3-((4-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzamido)pentanedioic acid

There total 6 articles about (R,Z)-2-(3-((4-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzamido)pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.1%

: 1384338-85-5
(R,Z)-dimethyl 2-(3-((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)-benzamido)pentanedioate

: 1384338-89-9
(R,Z)-2-(3-((4-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzamido)pentanedioic acid

Guidance literature:: With lithium hydroxide; In methanol; water; at 20 ℃;
DOI:10.1021/ml300047h

Reference yield:

: 623-27-8
terephthalaldehyde,

: 1384338-89-9
(R,Z)-2-(3-((4-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzamido)pentanedioic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / benzene / Reflux; Dean-Stark

2.1: sodium cyanotrihydroborate / methanol / 20 °C

3.1: pyridinium p-toluenesulfonate / tetrahydrofuran; water / 20 °C

4.1: piperidine; acetic acid / ethanol / 40 h / Reflux

5.1: O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.25 h

5.2: 5 h / 20 °C

6.1: lithium hydroxide / methanol; water / 20 °C

With piperidine; sodium cyanotrihydroborate; pyridinium p-toluenesulfonate; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; acetic acid; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; benzene; 4.1: |Knoevenagel Condensation;
DOI:10.1021/ml300047h

Reference yield:

: 1384338-77-5
3-((4-(1,3-dioxolan-2-yl)benzyl)amino)benzoic acid

: 1384338-89-9
(R,Z)-2-(3-((4-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)benzyl)amino)benzamido)pentanedioic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate / tetrahydrofuran; water / 20 °C

2.1: piperidine; acetic acid / ethanol / 40 h / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.25 h

3.2: 5 h / 20 °C

4.1: lithium hydroxide / methanol; water / 20 °C

With piperidine; pyridinium p-toluenesulfonate; O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 2.1: |Knoevenagel Condensation;
DOI:10.1021/ml300047h