(S)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol

Base Information

Chemical Name:(S)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol
CAS No.:663605-90-1
Molecular Formula:C₃₄H₅₀O₅Si
Molecular Weight:566.853
Hs Code.:

Synonyms:(S)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of (S)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol

There total 18 articles about (S)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 109-92-2,25104-37-4
ethyl vinyl ether

: 663606-11-9
(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentanecarbaldehyde

: 663605-90-1
(S)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol

: (R)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1002/anie.200353140

Reference yield:

: 156714-42-0
(1S,2R,3S,5S)-5-Isopropenyl-2-methyl-3-(tetrahydro-pyran-2-yloxy)-cyclopentanecarboxylic acid methyl ester

: 663605-90-1
(S)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol

: (R)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 11 steps

1: pyridinium p-toluenesulfonate / methanol / 40 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: sodium hydride / N,N-dimethyl-formamide / 20 °C

5: osmium(VIII) oxide; N-methyl-2-indolinone; water / acetone / 20 °C

6: sodium periodate / 20 °C

7: tetrahydrofuran / -78 °C

8: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

9: phosphate buffer; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 20 °C / pH 7

10: N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve / dichloromethane / 20 °C

11: tert.-butyl lithium / tetrahydrofuran / -78 °C

With 1H-imidazole; dmap; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; phosphate buffer; tetrapropylammonium perruthennate; 4 A molecular sieve; water; tert.-butyl lithium; pyridinium p-toluenesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1002/anie.200353140

Reference yield:

: 156629-27-5
(2R,3S,5S)-2-Chloro-5-isopropenyl-2-methyl-3-(tetrahydro-pyran-2-yloxy)-cyclohexanone

: 663605-90-1
(S)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol

: (R)-1-[(1R,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((S)-1-methoxymethoxy-1-methyl-but-3-enyl)-2-methyl-cyclopentyl]-2-ethoxy-prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 12 steps

1: sodium methylate / 0 °C

2: pyridinium p-toluenesulfonate / methanol / 40 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

5: sodium hydride / N,N-dimethyl-formamide / 20 °C

6: osmium(VIII) oxide; N-methyl-2-indolinone; water / acetone / 20 °C

7: sodium periodate / 20 °C

8: tetrahydrofuran / -78 °C

9: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

10: phosphate buffer; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 20 °C / pH 7

11: N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve / dichloromethane / 20 °C

12: tert.-butyl lithium / tetrahydrofuran / -78 °C

With 1H-imidazole; dmap; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; phosphate buffer; tetrapropylammonium perruthennate; 4 A molecular sieve; water; tert.-butyl lithium; sodium methylate; pyridinium p-toluenesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; 1: Favorskii rearrangement;
DOI:10.1002/anie.200353140