methyl 7-(4-propoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide

Base Information

Chemical Name:methyl 7-(4-propoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide
CAS No.:279261-53-9
Molecular Formula:C₂₁H₂₂O₅S
Molecular Weight:386.469
Hs Code.:

Synonyms:methyl 7-(4-propoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide

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Chemical Property of methyl 7-(4-propoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide

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Technology Process of methyl 7-(4-propoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide

There total 7 articles about methyl 7-(4-propoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 186497-67-6
4-n-propoxyboronic acid

: 279261-19-7
methyl 7-bromo-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide

: 279261-53-9
methyl 7-(4-propoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; Heating;
DOI:10.1248/cpb.52.577

Reference yield:

: 4-propoxyphenyl borate

: 279261-19-7
methyl 7-bromo-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide

: 279261-53-9
methyl 7-(4-propoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In ethanol; water; toluene;

Reference yield:

: 15084-55-6
7-bromo-3,4-dihydro-1-benzothiepin-5(2H)-one

: 279261-53-9
methyl 7-(4-propoxyphenyl)-2,3-dihydro-1-benzothiepine-4-carboxylate 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / sodium methoxide / 5 h / Heating

2: NaBH₄ / tetrahydrofuran; methanol / 1 h / -20 - -10 °C

3: Et₃N / tetrahydrofuran / 1.5 h / 0 - 20 °C

4: 37.2 g / 1,8-diazabicyclo[5,4,0]undec-7-ene / tetrahydrofuran / 0.17 h / 20 °C

5: 90 percent / aq. H₂O₂; acetic acid / 1 h / Heating

6: 76 percent / aq. K₂CO₃; Pd(PPh₃)4 / toluene; ethanol / Heating

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; sodium methylate; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; ethanol; toluene; 6: Suzuki coupling;
DOI:10.1248/cpb.52.577