tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate
• CAS No.: 209481-82-3
• Molecular Formula: C₂₅H₃₀ClN₃O₅S₂
• Molecular Weight: 552.115
• Mol file: 209481-82-3.mol

Synonyms:tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate

There total 4 articles about tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride (166964-33-6) + tert-butyl 4-(5-amino-2-methoxyphenyl)piperazine-1-carboxylate (148546-91-2) → tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate (209481-82-3)

Guidance literature:

With pyridine; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1021/jm980532e

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate (209481-82-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃ / tetrahydrofuran; H₂O / 18 h / Ambient temperature

2: 99 percent / H₂ / 10 percent Pd/C / ethanol / 18 h / Ambient temperature

3: 97 percent / pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1021/jm980532e

Reference yield:

1-(2-methoxy-5-nitrophenyl)piperazine (58315-37-0) → tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate (209481-82-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃ / tetrahydrofuran; H₂O / 18 h / Ambient temperature

2: 99 percent / H₂ / 10 percent Pd/C / ethanol / 18 h / Ambient temperature

3: 97 percent / pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1021/jm980532e

upstream raw materials:

5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride

tert-butyl 4-(5-amino-2-methoxyphenyl)piperazine-1-carboxylate

di-tert-butyl dicarbonate

1-(2-methoxy-5-nitrophenyl)piperazine

Downstream raw materials:

tert-butyl 4-[5-([(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]{[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)-2-methoxyphenyl]piperazine-1-carboxylate

tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][8-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate

tert-butyl 4-(5-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl][4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}-2-methoxyphenyl)piperazine-1-carboxylate