methyl 2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-carbnyl)amino)-3-hydroxypropanoate

Base Information

Chemical Name:methyl 2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-carbnyl)amino)-3-hydroxypropanoate
CAS No.:1328624-10-7
Molecular Formula:C₂₁H₂₀ClN₅O₅
Molecular Weight:457.873
Hs Code.:

Synonyms:methyl 2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-carbnyl)amino)-3-hydroxypropanoate

Suppliers and Price of methyl 2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-carbnyl)amino)-3-hydroxypropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-carbnyl)amino)-3-hydroxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-carbnyl)amino)-3-hydroxypropanoate

There total 6 articles about methyl 2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-carbnyl)amino)-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 2104-89-4,2788-84-3,24184-43-8
Ser-OMe

: 1352805-02-7
4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidine-5-carboxylic acid

: 1328624-10-7
methyl 2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-carbnyl)amino)-3-hydroxypropanoate

Guidance literature:: 4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidine-5-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

Ser-OMe; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 4786-52-1,71133-20-5
ethyl 4-hydroxypyrimidine-5-carboxylate

: 1328624-10-7
methyl 2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-carbnyl)amino)-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 5 h / 120 °C

2.1: isopropyl alcohol / 3 h

3.1: sodium hydroxide; water / ethanol / 2 h / 80 °C

3.2: 0 °C / pH 2 - 3 / Acidic conditions

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 4 h / 20 °C

With thionyl chloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; N,N-dimethyl-formamide; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1352805-02-7
4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidine-5-carboxylic acid

: 5619-04-5
methyl 2-amino-3-hydroxypropanoate hydrochloride

: 1328624-10-7
methyl 2-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-carbnyl)amino)-3-hydroxypropanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm201758g