2',5'-Di(tert-butyldimethylsilyl)-3'-(ethyl 4-(fluoromethyl)phenyl phosphate)uridine

Base Information

Chemical Name:2',5'-Di(tert-butyldimethylsilyl)-3'-(ethyl 4-(fluoromethyl)phenyl phosphate)uridine
CAS No.:169476-06-6
Molecular Formula:C₃₀H₅₀FN₂O₉PSi₂
Molecular Weight:688.878
Hs Code.:

Synonyms:2',5'-Di(tert-butyldimethylsilyl)-3'-(ethyl 4-(fluoromethyl)phenyl phosphate)uridine

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Chemical Property of 2',5'-Di(tert-butyldimethylsilyl)-3'-(ethyl 4-(fluoromethyl)phenyl phosphate)uridine

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Technology Process of 2',5'-Di(tert-butyldimethylsilyl)-3'-(ethyl 4-(fluoromethyl)phenyl phosphate)uridine

There total 7 articles about 2',5'-Di(tert-butyldimethylsilyl)-3'-(ethyl 4-(fluoromethyl)phenyl phosphate)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

: 169476-05-5
2',5'-Di(tert-butyldimethylsilyl)-3'-(ethyl 4-(hydroxymethyl)phenyl phosphate)uridine

: 169476-06-6
2',5'-Di(tert-butyldimethylsilyl)-3'-(ethyl 4-(fluoromethyl)phenyl phosphate)uridine

Guidance literature:: With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1021/jo00126a051

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 169476-06-6
2',5'-Di(tert-butyldimethylsilyl)-3'-(ethyl 4-(fluoromethyl)phenyl phosphate)uridine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 16 h

2: 94.9 percent / NaBH₄ / methanol; CH₂Cl₂ / 0.5 h / 0 °C

3: 78.6 percent / DAST / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; sodium tetrahydroborate; 4,4'-diaminostilbene-2,2'-disulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jo00126a051

Reference yield:

: 169476-04-4
Phosphorous acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester diethyl ester

: 169476-06-6
2',5'-Di(tert-butyldimethylsilyl)-3'-(ethyl 4-(fluoromethyl)phenyl phosphate)uridine

Guidance literature:: Multi-step reaction with 4 steps

1: I₂, Cl^(1-), pyridine / CH₂Cl₂ / 0.17 h / 0 °C

2: pyridine / 16 h

3: 94.9 percent / NaBH₄ / methanol; CH₂Cl₂ / 0.5 h / 0 °C

4: 78.6 percent / DAST / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; sodium tetrahydroborate; chloride; iodine; 4,4'-diaminostilbene-2,2'-disulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jo00126a051