Technology Process of (4S)-4-benzyl-2-(furan-2-ylvinyl)-2-oxazoline
There total 4 articles about (4S)-4-benzyl-2-(furan-2-ylvinyl)-2-oxazoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
thionyl chloride; potassium carbonate; sodium bromide;
In
acetonitrile;
for 4h;
Reflux;
DOI:10.1016/j.tetasy.2013.12.003
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h / 20 °C / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
2.2: 4 h / 20 °C / Inert atmosphere
3.1: thionyl chloride; potassium carbonate; sodium bromide / acetonitrile / 4 h / Reflux
With
dmap; thionyl chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; sodium bromide;
In
tetrahydrofuran; dichloromethane; acetonitrile;
2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tetasy.2013.12.003
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (bis-(2-methoxyethyl)amino)sulfur trufluoride; potassium carbonate / dichloromethane / -20 °C
2: N,N-dimethyl-formamide / 2 h / Reflux
With
potassium carbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
dichloromethane; N,N-dimethyl-formamide;
2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tetasy.2013.12.003
