5-chloro-2-nitro-N-trifluoroacetylaniline

Base Information

• Chemical Name: 5-chloro-2-nitro-N-trifluoroacetylaniline
• CAS No.: 174264-60-9
• Molecular Formula: C₈H₄ClF₃N₂O₃
• Molecular Weight: 268.58
• Mol file: 174264-60-9.mol

Synonyms:5-chloro-2-nitro-N-trifluoroacetylaniline

Chemical Property of 5-chloro-2-nitro-N-trifluoroacetylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-2-nitro-N-trifluoroacetylaniline

There total 2 articles about 5-chloro-2-nitro-N-trifluoroacetylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → 5-chloro-2-nitro-N-trifluoroacetylaniline (174264-60-9)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In dichloromethane; water;

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) + trifluoroacetic anhydride (407-25-0) → 5-chloro-2-nitro-N-trifluoroacetylaniline (174264-60-9)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; Ambient temperature;

DOI:10.1080/00397919608003827

Reference yield: 90.0%

dimethyl sulfate (77-78-1) + 5-chloro-2-nitro-N-trifluoroacetylaniline (174264-60-9) → 4-chloro-2-methylaminonitrobenzene (35966-84-8)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In toluene; Ambient temperature;

DOI:10.1080/00397919608003827

upstream raw materials:

5-chloro-2-nitroaniline

trifluoroacetic anhydride

Downstream raw materials:

4-chloro-2-methylaminonitrobenzene

Refernces

• 1、 -. "Azolyl methyl phenyl derivatives having aromatase inhibitory activity". . . Retrieved 2008/06/13.