3-(2-methyl-3-(trifluoromethyl)benzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

Base Information

• Chemical Name: 3-(2-methyl-3-(trifluoromethyl)benzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one
• CAS No.: 1374306-17-8
• Molecular Formula: C₁₉H₂₀F₃N₅O₂S
• Molecular Weight: 439.461

Synonyms:3-(2-methyl-3-(trifluoromethyl)benzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

Chemical Property of 3-(2-methyl-3-(trifluoromethyl)benzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

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Technology Process of 3-(2-methyl-3-(trifluoromethyl)benzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

There total 4 articles about 3-(2-methyl-3-(trifluoromethyl)benzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

morpholine (110-91-8,99108-56-2) + C15H12ClF3N4OS (1374306-35-0) → 3-(2-methyl-3-(trifluoromethyl)benzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one (1374306-17-8)

Guidance literature:

In ethanol; at 150 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.bmcl.2012.03.039

Reference yield:

C6H8N4O2S → 3-(2-methyl-3-(trifluoromethyl)benzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one (1374306-17-8)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 2 h / 80 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

3: ethanol / 1 h / 150 °C / Microwave irradiation

With potassium carbonate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.03.039

Reference yield:

C6H4Cl2N4S (1374306-27-0) → 3-(2-methyl-3-(trifluoromethyl)benzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one (1374306-17-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / 0.75 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

3: ethanol / 1 h / 150 °C / Microwave irradiation

With potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.03.039

upstream raw materials:

morpholine

C₁₅H₁₂ClF₃N₄OS

C₆H₄Cl₂N₄S

C₆H₅ClN₄OS

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