2,5-bis-p-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester

Base Information

• Chemical Name: 2,5-bis-p-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester
• CAS No.: 1026366-09-5
• Molecular Formula: C₂₆H₂₄N₄O₄S
• Molecular Weight: 488.567
• Mol file: 1026366-09-5.mol

Synonyms:2,5-bis-p-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester

Chemical Property of 2,5-bis-p-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-bis-p-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester

There total 2 articles about 2,5-bis-p-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-diamino-thiophene-3,4-dicarboxylic acid diethyl ester (80691-81-2) → 2,5-bis-p-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester (1026366-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / triethylamine / hexachloroethane; acetonitrile / 4 h / 20 °C

2: CH₂Cl₂ / 0 - 5 °C

With triethylamine; In dichloromethane; hexachloroethane; acetonitrile; 2: aza-Wittig reaction;

DOI:10.1021/jo048691v

Reference yield:

p-Tolylisocyanate (622-58-2,374675-64-6) + diethyl 2,5-bis[(triphenyl-λ5-phosphanylidene)amino]thiophene-3,4-dicarboxylate (147235-54-9) → 2,5-bis-p-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester (1026366-09-5)

Guidance literature:

In dichloromethane; at 0 - 5 ℃;

DOI:10.1021/jo048691v

Reference yield: 70.0%

2,5-bis-p-tolyliminomethyleneamino-thiophene-3,4-dicarboxylic acid diethyl ester (1026366-09-5) + 4-bromo-phenol (106-41-2) → 2,7-bis(4-bromophenoxy)-3,6-bis(4-methylphenyl)-3,4,5,6-tetrahydrothieno[2,3-d:5,4-d']dipyrimidine-4,5-dione

Guidance literature:

With potassium carbonate; In acetonitrile; at 40 - 50 ℃;

DOI:10.1021/jo048691v

upstream raw materials:

p-Tolylisocyanate

diethyl 2,5-bis[(triphenyl-λ⁵-phosphanylidene)amino]thiophene-3,4-dicarboxylate

2,5-diamino-thiophene-3,4-dicarboxylic acid diethyl ester