2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonyloxy-2-difluoromethyl-phenyl)-propionic acid ethyl ester

Base Information

Chemical Name:2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonyloxy-2-difluoromethyl-phenyl)-propionic acid ethyl ester
CAS No.:133409-97-9
Molecular Formula:C₃₀H₃₁F₂NO₅
Molecular Weight:523.577
Hs Code.:

Synonyms:2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonyloxy-2-difluoromethyl-phenyl)-propionic acid ethyl ester

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Chemical Property of 2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonyloxy-2-difluoromethyl-phenyl)-propionic acid ethyl ester

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Technology Process of 2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonyloxy-2-difluoromethyl-phenyl)-propionic acid ethyl ester

There total 9 articles about 2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonyloxy-2-difluoromethyl-phenyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 69555-14-2
ethyl N-diphenylmethylene glycine

: 139191-92-7
1-tert-Butoxycarbonyloxy-3-difluoromethyl-4-bromomethyl Benzene

: 133409-97-9
2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonyloxy-2-difluoromethyl-phenyl)-propionic acid ethyl ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(00)92112-9

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 133409-97-9
2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonyloxy-2-difluoromethyl-phenyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N, DMAP / tetrahydrofuran / 1 h / Ambient temperature

2: 70 percent / N-bromosuccinimide / CCl₄ / 2 h / Irradiation

3: 73 percent / LiN3)3>2 / tetrahydrofuran / -78 °C

With dmap; N-Bromosuccinimide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane;
DOI:10.1016/S0040-4039(00)92112-9

Reference yield:

: 34265-55-9
ethyl 3-hydroxy-6-methylbenzoate

: 133409-97-9
2-(Benzhydrylidene-amino)-3-(4-tert-butoxycarbonyloxy-2-difluoromethyl-phenyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: NaI, K₂CO₃ / acetone / Heating

2: DIBAL / toluene / 0 °C

3: (COCl)2, DMSO, NEt₃ / CH₂Cl₂

4: 90 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 16 h / Ambient temperature

5: CF₃CO₂H / CH₂Cl₂ / 1 h / Ambient temperature

6: Et₃N, DMAP / tetrahydrofuran / 1 h / Ambient temperature

7: 70 percent / N-bromosuccinimide / CCl₄ / 2 h / Irradiation

8: 73 percent / LiN3)3>2 / tetrahydrofuran / -78 °C

With dmap; N-Bromosuccinimide; oxalyl dichloride; diethylamino-sulfur trifluoride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane; dichloromethane; acetone; toluene;
DOI:10.1016/S0040-4039(00)92112-9