N^α-(1,1-dimethylethoxycarbonyl)-trans-4-(2-cyanomethyl)-L-proline methyl ester

Base Information

Chemical Name:N^α-(1,1-dimethylethoxycarbonyl)-trans-4-(2-cyanomethyl)-L-proline methyl ester
CAS No.:327989-70-8
Molecular Formula:C₁₃H₂₀N₂O₄
Molecular Weight:268.313
Hs Code.:

N<sup>α</sup>-(1,1-dimethylethoxycarbonyl)-trans-4-(2-cyanomethyl)-L-proline methyl ester

Synonyms:N^α-(1,1-dimethylethoxycarbonyl)-trans-4-(2-cyanomethyl)-L-proline methyl ester

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Chemical Property of N^α-(1,1-dimethylethoxycarbonyl)-trans-4-(2-cyanomethyl)-L-proline methyl ester

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Technology Process of N^α-(1,1-dimethylethoxycarbonyl)-trans-4-(2-cyanomethyl)-L-proline methyl ester

There total 1 articles about N^α-(1,1-dimethylethoxycarbonyl)-trans-4-(2-cyanomethyl)-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 327989-70-8
N^α-(1,1-dimethylethoxycarbonyl)-trans-4-(2-cyanomethyl)-L-proline methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 17.7 g / triethylamine / dimethylformamide / 1.5 h / 55 °C

2: 90 percent / N-methylmorpholine-N-oxide; 4 Angstroem molecular sieves; tetrapropylammonium perruthenate / CH₂Cl₂ / 3.5 h / 35 °C

3: lithium hexamethyldisilazide / tetrahydrofuran / 0.92 h / 0 - 20 °C

4: 1.19 g / H₂ / PdCl₂ / methanol / 24 h / 2327.17 Torr

With tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; 4-methylmorpholine N-oxide; triethylamine; lithium hexamethyldisilazane; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tetlet.2005.05.093

Reference yield:

: 327989-70-8
N^α-(1,1-dimethylethoxycarbonyl)-trans-4-(2-cyanomethyl)-L-proline methyl ester

: 147235-94-7,168034-53-5,168034-55-7
(2S,4S)-4-(carboxymethyl)pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1N NaOH / 2.5 h / Heating

2: CH₂Cl₂ / 0.5 h / 20 °C

With sodium hydroxide; In dichloromethane;
DOI:10.1016/j.tetlet.2005.05.093