methyl-phenyl-carbamic acid 5-(4-chloromethyl-benzoylamino)-pyridin-2-yl ester

Base Information

• Chemical Name: methyl-phenyl-carbamic acid 5-(4-chloromethyl-benzoylamino)-pyridin-2-yl ester
• CAS No.: 812639-66-0
• Molecular Formula: C₂₁H₁₈ClN₃O₃
• Molecular Weight: 395.845

Synonyms:methyl-phenyl-carbamic acid 5-(4-chloromethyl-benzoylamino)-pyridin-2-yl ester

Chemical Property of methyl-phenyl-carbamic acid 5-(4-chloromethyl-benzoylamino)-pyridin-2-yl ester

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Technology Process of methyl-phenyl-carbamic acid 5-(4-chloromethyl-benzoylamino)-pyridin-2-yl ester

There total 1 articles about methyl-phenyl-carbamic acid 5-(4-chloromethyl-benzoylamino)-pyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl-phenyl-carbamic acid 5-amino-pyridin-2-yl ester (548769-49-9) + p-(chloromethyl)benzoyl chloride (876-08-4) → methyl-phenyl-carbamic acid 5-(4-chloromethyl-benzoylamino)-pyridin-2-yl ester (812639-66-0)

Guidance literature:

With triethylamine; In DMF (N,N-dimethyl-formamide); dichloromethane; at 20 ℃; for 1h;

Reference yield: 64.0%

methyl-phenyl-carbamic acid 5-(4-chloromethyl-benzoylamino)-pyridin-2-yl ester (812639-66-0) + 3-Methylpiperidine (626-56-2,53152-98-0) → methyl-phenyl-carbamic acid 5-[4-(3-methyl-piperidin-1-ylmethyl)-benzoylamino]-pyridin-2-yl ester (812639-73-9)

Guidance literature:

sodium iodide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 18h;

Reference yield: 64.0%

methyl-phenyl-carbamic acid 5-(4-chloromethyl-benzoylamino)-pyridin-2-yl ester (812639-66-0) + 2-Methylpiperidin (109-05-7,3000-79-1) → methyl-phenyl-carbamic acid 5-[4-(2-methyl-piperidin-1-ylmethyl)-benzoylamino]-pyridin-2-yl ester (812639-71-7)

Guidance literature:

sodium iodide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 18h;

upstream raw materials:

methyl-phenyl-carbamic acid 5-amino-pyridin-2-yl ester

p-(chloromethyl)benzoyl chloride

Downstream raw materials:

methyl-phenyl-carbamic acid 5-[4-(3-methyl-piperidin-1-ylmethyl)-benzoylamino]-pyridin-2-yl ester

methyl-phenyl-carbamic acid 5-[4-(2-methyl-piperidin-1-ylmethyl)-benzoylamino]-pyridin-2-yl ester

methyl-phenyl-carbamic acid 5-(4-dimethylaminomethyl-benzoylamino)-pyridin-2-yl ester trifluoroacetic acid salt

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