4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl trifluoromethanesulfonate
• CAS No.: 643093-72-5
• Molecular Formula: C₂₂H₂₅ClF₃NO₆S
• Molecular Weight: 523.958

Synonyms:4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl trifluoromethanesulfonate

Chemical Property of 4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl trifluoromethanesulfonate

There total 1 articles about 4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 2-(4-hydroxyphenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate (150014-08-7) + trifluoromethylsulfonic anhydride (358-23-6) → 4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl trifluoromethanesulfonate (643093-72-5)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at -70 ℃; for 0.5h;

DOI:10.1021/jm701324c

Reference yield: 67.0%

4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl trifluoromethanesulfonate (643093-72-5) + 4-methoxycarbonylphenylboronic acid (99768-12-4) → methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)-1,1'-biphenyl-4-carboxylate (643093-50-9)

Guidance literature:

With sodium carbonate; Ph(PPh₃)4; In 1,2-dimethoxyethane; at 70 ℃;

DOI:10.1021/jm701324c

Reference yield:

3-fluoro-4-methoxycarbonylphenylboronic acid (505083-04-5) + 4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl trifluoromethanesulfonate (643093-72-5) → methyl 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-3-fluoro-1,1'-biphenyl-4-carboxylate (643091-31-0)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane;

upstream raw materials:

tert-butyl 2-(4-hydroxyphenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate

trifluoromethylsulfonic anhydride

Downstream raw materials:

methyl 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-3-fluoro-1,1'-biphenyl-4-carboxylate

methyl 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-3-methyl-1,1'-biphenyl-4-carboxylate

methyl 4'-[2-[N-(tert-butoxycarbonyl)-N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-3-chloro-1,1'-biphenyl-4-carboxylate

methyl 4'-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]-3-(cyclohexyloxy)-4-biphenylcarboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 643093-72-5 4-(2-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl trifluoromethanesulfonate

Send

Send

Metric Ton KG G Pound L ML

Send

Send