6,7-dimethoxy-1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:6,7-dimethoxy-1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1374870-00-4
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:6,7-dimethoxy-1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 6,7-dimethoxy-1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 6,7-dimethoxy-1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 6,7-dimethoxy-1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 16620-96-5
2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

4-ethynylveratrole: 4302-52-7
4-ethynylveratrole

: 1374870-00-4
6,7-dimethoxy-1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; With diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 1h;

4-ethynylveratrole; With copper(l) iodide; In tetrahydrofuran; at 20 ℃; regioselective reaction;
DOI:10.1055/s-0031-1290532

Reference yield:

: 97243-37-3,92632-93-4
3-(3',4'-dimethoxyphenyl)-2,3-dibromopropanoic acid

: 1374870-00-4
6,7-dimethoxy-1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / water / Reflux

2.1: potassium hydroxide / water

3.1: diethylazodicarboxylate / tetrahydrofuran / 1 h / 20 °C

3.2: 20 °C

With sodium carbonate; potassium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; water;
DOI:10.1055/s-0031-1290532

Reference yield:

: 69731-27-7,92632-94-5
1-bromo-2-(3',4'-dimethoxyphenyl)ethene

: 1374870-00-4
6,7-dimethoxy-1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / water

2.1: diethylazodicarboxylate / tetrahydrofuran / 1 h / 20 °C

2.2: 20 °C

With potassium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; water;
DOI:10.1055/s-0031-1290532