2-Methyl-6-((3-((2-phenyl-4-oxazolyl)methoxy)propoxy)methyl)benzoic acid

Base Information

Chemical Name:2-Methyl-6-((3-((2-phenyl-4-oxazolyl)methoxy)propoxy)methyl)benzoic acid
CAS No.:304025-09-0
Molecular Formula:C₂₂H₂₃NO₅
Molecular Weight:381.428
Hs Code.:
UNII:O9SA2C9EII

Synonyms:2-methyl-6-(3-(2-phenyloxazol-4-ylmethoxy)propoxymethyl)benzoic acid;AVE 8134;AVE-8134;AVE8134

Suppliers and Price of 2-Methyl-6-((3-((2-phenyl-4-oxazolyl)methoxy)propoxy)methyl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Methyl-6-((3-((2-phenyl-4-oxazolyl)methoxy)propoxy)methyl)benzoic acid

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:381.15762283
Heavy Atom Count:28
Complexity:468

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)COCCCOCC2=COC(=N2)C3=CC=CC=C3)C(=O)O
Recent EU Clinical Trials:Estudio aleatorizado de 12 semanas, multicéntrico, doble ciego, controlado con placebo, , de la eficacia y seguridad de comprimidos de AVE8134 1,0 mg en la disminución de A1c en el tratamiento de pacientes con diabetes mellitus tipo 2 confirmada que no estén recibiendo tratamiento farmacológico.

Technology Process of 2-Methyl-6-((3-((2-phenyl-4-oxazolyl)methoxy)propoxy)methyl)benzoic acid

There total 2 articles about 2-Methyl-6-((3-((2-phenyl-4-oxazolyl)methoxy)propoxy)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 304025-26-1
3-(2-Phenyl-oxazol-4-ylmethoxy)-propan-1-ol

: 765937-39-1
methyl 2-iodomethyl-6-methylbenzoate

: 304025-09-0
2-Methyl-6-[3-(2-phenyl-oxazol-4-ylmethoxy)-propoxymethyl]-benzoic Acid

Guidance literature:: With potassium tert-butylate; In toluene; at -20 ℃; for 6.16667h;

Reference yield:

: 304025-08-9
isobutyl 2-methyl-6-[3-(2-phenyl-oxazol-4-ylmethoxy)-propoxymethyl]-benzoate

: 304025-09-0
2-Methyl-6-[3-(2-phenyl-oxazol-4-ylmethoxy)-propoxymethyl]-benzoic Acid

Guidance literature:

Reference yield: 73.0%

: 304025-09-0
2-Methyl-6-[3-(2-phenyl-oxazol-4-ylmethoxy)-propoxymethyl]-benzoic Acid

: C₂₂H₂₁⁽²⁾H₂NO₅

Guidance literature:: With triphenylphosphine(1,5-cyclooctadiene)[1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene]iridium(I) hexafluorophosphate; deuterium; In tetrahydrofuran; at 50 ℃; for 1h; under 760.051 Torr; Solvent; Temperature; Sealed tube;
DOI:10.1016/j.tet.2015.02.029