2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

Base Information

Chemical Name:2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid
CAS No.:691857-10-0
Molecular Formula:C₁₉H₁₈FNO₆S
Molecular Weight:407.419
Hs Code.:

Synonyms:2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

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Chemical Property of 2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

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Technology Process of 2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

There total 8 articles about 2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1217340-86-7
methyl 2-(4-fluorophenyl)-5-isopropoxy-6-(methylsulfonamido)benzofuran-3-carboxylate

: 691857-10-0
2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

Guidance literature:: methyl 2-(4-fluorophenyl)-5-isopropoxy-6-(methylsulfonamido)benzofuran-3-carboxylate; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 60 - 67 ℃;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: 1331942-90-5
methyl 6-[bis(methylsulfonyl)amino]-2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-1-benzofuran-3-carboxylate

: 691857-10-0
2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

Guidance literature:: methyl 6-[bis(methylsulfonyl)amino]-2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-1-benzofuran-3-carboxylate; With methanol; sodium hydroxide; In tetrahydrofuran; at 80 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 63131-29-3
methyl 4-fluorobenzoyl acetate

: 691857-10-0
2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: zinc(II) chloride / diethyl ether; methanol / 7.5 h / 75 - 115 °C / Inert atmosphere

2: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 60 °C / Inert atmosphere

3: nitric acid / chloroform / 1 h / -15 - 0 °C

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 21 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

6: sodium hydroxide; methanol / tetrahydrofuran / 16 h / 80 °C

With methanol; hydrogen; nitric acid; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane; chloroform; ethyl acetate;