H-Pro₂-Leu₃-OBzl*HCl

Base Information

• Chemical Name: H-Pro₂-Leu₃-OBzl*HCl
• CAS No.: 75666-43-2
• Molecular Formula: C₃₅H₅₅N₅O₆*ClH
• Molecular Weight: 678.313
• Mol file: 75666-43-2.mol

Synonyms:H-Pro₂-Leu₃-OBzl*HCl

Chemical Property of H-Pro₂-Leu₃-OBzl*HCl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-Pro₂-Leu₃-OBzl*HCl

There total 6 articles about H-Pro₂-Leu₃-OBzl*HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L?proline benzyl ester p?toluenesulfonate (32302-87-7) → H-Pro2-Leu3-OBzl*HCl (75666-43-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-methylmorpholine (NMM), 1-hydroxyl-1H-benzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran / 0 - 20 °C

2: H₂ / 5percent Pd/C / methanol; acetic acid / 760 Torr / Ambient temperature

3: 82 percent / N-methylmorpholine (NMM), 1-hydroxyl-1H-benzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran / 0 - 20 °C

4: 3M HCl / ethyl acetate

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate;

DOI:10.1246/bcsj.53.1028

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → H-Pro2-Leu3-OBzl*HCl (75666-43-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-methylmorpholine (NMM), 1-hydroxyl-1H-benzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran / 0 - 20 °C

2: H₂ / 5percent Pd/C / methanol; acetic acid / 760 Torr / Ambient temperature

3: 82 percent / N-methylmorpholine (NMM), 1-hydroxyl-1H-benzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran / 0 - 20 °C

4: 3M HCl / ethyl acetate

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate;

DOI:10.1246/bcsj.53.1028

Reference yield:

Boc-Pro2-Leu3-OBzl (75666-42-1) → H-Pro2-Leu3-OBzl*HCl (75666-43-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1246/bcsj.53.1028

upstream raw materials:

Boc-Pro₂-Leu₃-OBzl

1-(tert-butoxycarbonyl)-L-proline

N-tert-butoxycarbonyl-L-prolyl-L-proline

L?proline benzyl ester p?toluenesulfonate

Downstream raw materials:

Boc-Ala₂-Leu₃-Pro₂-Leu₃-OBzl