(E)-1-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-3-(4-fluoro-phenyl)-propenone

Base Information

Chemical Name:(E)-1-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-3-(4-fluoro-phenyl)-propenone
CAS No.:204073-23-4
Molecular Formula:C₁₆H₁₈FNO₃
Molecular Weight:291.322
Hs Code.:

Synonyms:(E)-1-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-3-(4-fluoro-phenyl)-propenone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-3-(4-fluoro-phenyl)-propenone

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Technology Process of (E)-1-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-3-(4-fluoro-phenyl)-propenone

There total 1 articles about (E)-1-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-3-(4-fluoro-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-32-5
(E)-4-fluorocinnamic acid

: 204073-23-4
(E)-1-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-3-(4-fluoro-phenyl)-propenone

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / CH₂Cl₂; dimethylformamide / 8 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970595h

Reference yield: 79.0%

: 204073-23-4
(E)-1-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-3-(4-fluoro-phenyl)-propenone

: 204073-24-5
8-[(E)-3-(4-Fluoro-phenyl)-allyl]-1,4-dioxa-8-aza-spiro[4.5]decane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jm970595h

Reference yield:

: 204073-23-4
(E)-1-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-3-(4-fluoro-phenyl)-propenone

: 204073-33-6
1-[3-(4'-fluorophenyl)propyl]-4-(2-hydroxyethyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

2: 61 percent / aq. HCl / benzene / 24 h / Heating

3: 1.) NaH / 1.) THF, a) RT, 10 min, b) reflux, 15 min

4: 96 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

5: 90 percent / H₂ / 10percent Pd/C / ethanol / 8 h

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; benzene;
DOI:10.1021/jm970595h