Technology Process of 7-(2-iodo-6-methoxyphenoxy)-1,4-dioxaspiro[4.5]decan-8-one
There total 4 articles about 7-(2-iodo-6-methoxyphenoxy)-1,4-dioxaspiro[4.5]decan-8-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C15H19IO5;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 1.5h;
With
triethylamine;
In
dichloromethane;
at -78 - 20 ℃;
for 2h;
DOI:10.1021/ol300913g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: C55H50Cl2N2P2Ru; potassium tert-butylate; hydrogen / isopropyl alcohol / 3 h / 30 °C / 22801.5 Torr / Autoclave
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
2.2: 2 h / -78 - 20 °C
With
oxalyl dichloride; C55H50Cl2N2P2Ru; potassium tert-butylate; hydrogen; dimethyl sulfoxide;
In
dichloromethane; isopropyl alcohol;
2.1: Swern oxidation;
DOI:10.1021/ol300913g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C
2.1: C55H50Cl2N2P2Ru; potassium tert-butylate; hydrogen / isopropyl alcohol / 3 h / 30 °C / 22801.5 Torr / Autoclave
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
3.2: 2 h / -78 - 20 °C
With
oxalyl dichloride; C55H50Cl2N2P2Ru; potassium tert-butylate; hydrogen; potassium carbonate; dimethyl sulfoxide;
In
dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
3.1: Swern oxidation;
DOI:10.1021/ol300913g
