(2R,3S,E)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-5-iodo-2,4-dimethylpent-4-enoate

Base Information

Chemical Name:(2R,3S,E)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-5-iodo-2,4-dimethylpent-4-enoate
CAS No.:942133-13-3
Molecular Formula:C₃₂H₃₈INO₅S
Molecular Weight:675.628
Hs Code.:

Synonyms:(2R,3S,E)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-5-iodo-2,4-dimethylpent-4-enoate

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Chemical Property of (2R,3S,E)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-5-iodo-2,4-dimethylpent-4-enoate

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Technology Process of (2R,3S,E)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-5-iodo-2,4-dimethylpent-4-enoate

There total 2 articles about (2R,3S,E)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-5-iodo-2,4-dimethylpent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 106484-89-3
(E)-3-iodo-2-methylprop-2-enal

: 187324-66-9
(1R,2S)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate

: 942133-13-3
(2R,3S,E)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-5-iodo-2,4-dimethylpent-4-enoate

Guidance literature:: (1R,2S)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate; With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; at -78 ℃; for 5h; Inert atmosphere;

(E)-3-iodo-2-methylprop-2-enal; In hexane; dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With dihydrogen peroxide; In methanol; hexane; dichloromethane; at 20 ℃; pH=7; optical yield given as %de; stereoselective reaction; aq. buffer;
DOI:10.1021/jo901565n

Reference yield:

: 106484-89-3
(E)-3-iodo-2-methylprop-2-enal

: 187324-66-9
(1R,2S)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate

: 942133-13-3
(2R,3S,E)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-5-iodo-2,4-dimethylpent-4-enoate

: C₃₂H₃₈INO₅S

Guidance literature:: (1R,2S)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate; With triethylamine; In hexane; dichloromethane; at -78 ℃; for 5h;

(E)-3-iodo-2-methylprop-2-enal; In hexane; dichloromethane; at -78 - 20 ℃; for 3h;

With dihydrogen peroxide; In methanol; hexane; dichloromethane; at 20 ℃; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja071461o