N,N'-([1,1'-biphenyl]-4,4'-diyldi-2,1-ethanediyl)-bis-methanesulfonamide

Base Information

Chemical Name:N,N'-([1,1'-biphenyl]-4,4'-diyldi-2,1-ethanediyl)-bis-methanesulfonamide
CAS No.:516491-32-0
Molecular Formula:C₁₈H₂₄N₂O₄S₂
Molecular Weight:396.532
Hs Code.:

Synonyms:N,N'-([1,1'-biphenyl]-4,4'-diyldi-2,1-ethanediyl)-bis-methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N'-([1,1'-biphenyl]-4,4'-diyldi-2,1-ethanediyl)-bis-methanesulfonamide

Chemical Property:

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Technology Process of N,N'-([1,1'-biphenyl]-4,4'-diyldi-2,1-ethanediyl)-bis-methanesulfonamide

There total 8 articles about N,N'-([1,1'-biphenyl]-4,4'-diyldi-2,1-ethanediyl)-bis-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

: 375345-98-5
propane-2-sulfonic acid (2-(4-iodophenyl)propyl)amide

: 375346-00-2
[4-[2-[(methylsulfonyl)amino]ethyl]phenyl]boronic acid

: 375345-95-2
{(2R)-2-[4-(4-{2-[(methylsulfonyl)amino]ethyl}phenyl)phenyl]-propyl}[(methylethyl)sulfonyl]amine

: 516491-32-0
N,N'-([1,1'-biphenyl]-4,4'-diyldi-2,1-ethanediyl)-bis-methanesulfonamide

: ((2R)-2-{4-[4-((1R)-1-methyl-2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl]phenyl}propyl)[(methylethyl)sulfonyl]amine

Guidance literature:: With potassium formate; In water; pH=8;

propane-2-sulfonic acid (2-(4-iodophenyl)propyl)amide; [4-[2-[(methylsulfonyl)amino]ethyl]phenyl]boronic acid; With propan-1-ol; potassium carbonate; In water; for 0.716667h; under 10 Torr; Under nitrogen;

palladium; for 16h; Heating / reflux; Under nitrogen;

Reference yield:

: 375345-98-5
propane-2-sulfonic acid (2-(4-iodophenyl)propyl)amide

: 375346-00-2
[4-[2-[(methylsulfonyl)amino]ethyl]phenyl]boronic acid

: 375345-95-2
{(2R)-2-[4-(4-{2-[(methylsulfonyl)amino]ethyl}phenyl)phenyl]-propyl}[(methylethyl)sulfonyl]amine

: 516491-32-0
N,N'-([1,1'-biphenyl]-4,4'-diyldi-2,1-ethanediyl)-bis-methanesulfonamide

Guidance literature:: With palladium diacetate; potassium carbonate; pyrographite; In propan-1-ol; water; at 80 ℃; for 24h; Concentration; Time; Reagent/catalyst; Inert atmosphere;
DOI:10.1021/op060180i

Reference yield:

: 353235-93-5
N-(2-(4-iodophenyl)ethyl)-N-(methylsulfonyl)amine

: 375345-95-2
{(2R)-2-[4-(4-{2-[(methylsulfonyl)amino]ethyl}phenyl)phenyl]-propyl}[(methylethyl)sulfonyl]amine

: 516491-32-0
N,N'-([1,1'-biphenyl]-4,4'-diyldi-2,1-ethanediyl)-bis-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / dichloromethane / 20 °C

2.1: triethylamine / 1,1'-bis(diphenylphosphino) ferrocene-dichloropalladium (II)-CH₂Cl₂ complex / acetonitrile / 8 h / 70 - 74 °C

3.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

4.1: water; acetone / 20 °C

5.1: potassium formate / water / pH 8

5.2: 0.72 h / 10 Torr / Under nitrogen

5.3: 16 h / Heating / reflux; Under nitrogen

With dmap; potassium formate; triethylamine; trifluoroacetic acid; 1,1'-bis(diphenylphosphino) ferrocene-dichloropalladium (II)-CH₂Cl₂ complex; In dichloromethane; water; acetone; acetonitrile;