3-[(3-chloro-propyl)-(1-methyl-1H-pyrrole-3-carbonyl)-amino]-propionic acid

Base Information

Chemical Name:3-[(3-chloro-propyl)-(1-methyl-1H-pyrrole-3-carbonyl)-amino]-propionic acid
CAS No.:191591-77-2
Molecular Formula:C₁₂H₁₇ClN₂O₃
Molecular Weight:272.732
Hs Code.:

3-[(3-chloro-propyl)-(1-methyl-1<i>H</i>-pyrrole-3-carbonyl)-amino]-propionic acid

Synonyms:3-[(3-chloro-propyl)-(1-methyl-1H-pyrrole-3-carbonyl)-amino]-propionic acid

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Chemical Property of 3-[(3-chloro-propyl)-(1-methyl-1H-pyrrole-3-carbonyl)-amino]-propionic acid

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Technology Process of 3-[(3-chloro-propyl)-(1-methyl-1H-pyrrole-3-carbonyl)-amino]-propionic acid

There total 1 articles about 3-[(3-chloro-propyl)-(1-methyl-1H-pyrrole-3-carbonyl)-amino]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36929-61-0
1-methyl-pyrrole-3-carboxylic acid

: 191591-77-2
3-[(3-chloro-propyl)-(1-methyl-1H-pyrrole-3-carbonyl)-amino]-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine; Et₃N / CH₂Cl₂ / 5 h / 20 °C

2: 2 N aq. NaOH / tetrahydrofuran / 0.5 h / 20 °C

With dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; 1: Acylation / 2: Hydrolysis;
DOI:10.1248/cpb.48.623

Reference yield:

: 191591-77-2
3-[(3-chloro-propyl)-(1-methyl-1H-pyrrole-3-carbonyl)-amino]-propionic acid

: 5-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-1-methyl-1,4,5,6,7,8-hexahydropyrrolo[3,2-c]azepin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / P₂O₅; CH₃SO₃H / 0.5 h / 90 °C

2: 100 percent / K₂CO₃; NaI / acetonitrile / 38 h / Heating

3: 89 percent / NaBH₄ / ethanol / 17 h / 0 - 20 °C

4: 89 percent / HCl / CHCl₃ / 2 h / 20 °C

5: 100 percent / H₂; AcOH / 10 percent Pd/C / ethanol / 20 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; methanesulfonic acid; hydrogen; phosphorus pentoxide; potassium carbonate; acetic acid; sodium iodide; palladium on activated charcoal; In ethanol; chloroform; acetonitrile; 1: Cyclization / 2: Alkylation / 3: Reduction / 4: Dehydration / 5: Catalytic hydrogenation;
DOI:10.1248/cpb.48.623

Reference yield:

: 191591-77-2
3-[(3-chloro-propyl)-(1-methyl-1H-pyrrole-3-carbonyl)-amino]-propionic acid

: 191591-93-2
1-methyl-5-[3-(4-phenylpiperazin-1-yl)-propyl]-1,4,5,6,7,8-hexahydropyrrolo[3,2-c]azepine-4,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / P₂O₅; CH₃SO₃H / 0.5 h / 90 °C

2: K₂CO₃; NaI / acetonitrile / 38 h / Heating

With methanesulfonic acid; phosphorus pentoxide; potassium carbonate; sodium iodide; In acetonitrile; 1: Cyclization / 2: Alkylation;
DOI:10.1248/cpb.48.623