methyl 2-((4-(dimethylamino)phenyl)(hydroxy)methyl)acrylate

Base Information

• Chemical Name: methyl 2-((4-(dimethylamino)phenyl)(hydroxy)methyl)acrylate
• CAS No.: 500163-46-2
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.283
• Mol file: 500163-46-2.mol

Synonyms:methyl 2-((4-(dimethylamino)phenyl)(hydroxy)methyl)acrylate

Chemical Property of methyl 2-((4-(dimethylamino)phenyl)(hydroxy)methyl)acrylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 2-((4-(dimethylamino)phenyl)(hydroxy)methyl)acrylate

There total 3 articles about methyl 2-((4-(dimethylamino)phenyl)(hydroxy)methyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + 4-dimethylamino-benzaldehyde (100-10-7) → methyl 2-((4-(dimethylamino)phenyl)(hydroxy)methyl)acrylate (500163-46-2)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; acetic acid; In neat (no solvent); at 20 ℃; for 288h;

DOI:10.1002/ejoc.202101448

Reference yield:

C19H29BFNO5 → methyl 2-((4-(dimethylamino)phenyl)(hydroxy)methyl)acrylate (500163-46-2)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201802023

Reference yield:

4-dimethylamino-benzaldehyde (100-10-7) → methyl 2-((4-(dimethylamino)phenyl)(hydroxy)methyl)acrylate (500163-46-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; CuF(PPh₃)3 / toluene / 20 °C / Schlenk technique; Inert atmosphere

2: sodium methylate / methanol / 24 h / 20 °C / Inert atmosphere; Schlenk technique

With 1,1'-bis-(diphenylphosphino)ferrocene; CuF(PPh₃)3; sodium methylate; In methanol; toluene;

DOI:10.1002/chem.201802023

upstream raw materials:

acrylic acid methyl ester

4-dimethylamino-benzaldehyde