1-(2,3-dideoxy-3-fluoro-5-O-trityl-β-D-erythro-pentofuranosyl)-5-ethyluracil

Base Information

Chemical Name:1-(2,3-dideoxy-3-fluoro-5-O-trityl-β-D-erythro-pentofuranosyl)-5-ethyluracil
CAS No.:1006598-06-6
Molecular Formula:C₃₀H₂₉FN₂O₄
Molecular Weight:500.57
Hs Code.:

Synonyms:1-(2,3-dideoxy-3-fluoro-5-O-trityl-β-D-erythro-pentofuranosyl)-5-ethyluracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,3-dideoxy-3-fluoro-5-O-trityl-β-D-erythro-pentofuranosyl)-5-ethyluracil

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Technology Process of 1-(2,3-dideoxy-3-fluoro-5-O-trityl-β-D-erythro-pentofuranosyl)-5-ethyluracil

There total 3 articles about 1-(2,3-dideoxy-3-fluoro-5-O-trityl-β-D-erythro-pentofuranosyl)-5-ethyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 105380-85-6
1-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-5-ethyluracil

: 1006598-06-6
1-(2,3-dideoxy-3-fluoro-5-O-trityl-β-D-erythro-pentofuranosyl)-5-ethyluracil

Guidance literature:: With diethylamino-sulfur trifluoride; In tetrahydrofuran; benzene; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2011.11.114

Reference yield: 66.6%

: 67912-88-3,105380-85-6
5'-O-Trityl-5-ethyl-2'-deoxyuridine

: 1006598-06-6
1-(2,3-dideoxy-3-fluoro-5-O-trityl-β-D-erythro-pentofuranosyl)-5-ethyluracil

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 ℃; for 1.5h;

Reference yield:

: 15176-29-1
edoxudine

: 1006598-06-6
1-(2,3-dideoxy-3-fluoro-5-O-trityl-β-D-erythro-pentofuranosyl)-5-ethyluracil

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 4 h / 50 °C

2: pyridine

3: 1 N NaOH / ethanol; H₂O / 5 h / Heating

4: (diethylaminosulfur)trifluoride / benzene / 2 h / Ambient temperature

With pyridine; sodium hydroxide; diethylamino-sulfur trifluoride; In ethanol; water; benzene;
DOI:10.1021/jm00391a003