3-(3'-hydroxybiphenyl-3-yl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 3-(3'-hydroxybiphenyl-3-yl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine
• CAS No.: 1443986-15-9
• Molecular Formula: C₂₉H₂₁N₃O₂S
• Molecular Weight: 475.571
• Mol file: 1443986-15-9.mol

Synonyms:3-(3'-hydroxybiphenyl-3-yl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine

Chemical Property of 3-(3'-hydroxybiphenyl-3-yl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3'-hydroxybiphenyl-3-yl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine

There total 5 articles about 3-(3'-hydroxybiphenyl-3-yl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-(3-bromophenyl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine (1443986-46-6) + 3-hydroxyphenylboronic acid (87199-18-6) → 3-(3'-hydroxybiphenyl-3-yl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine (1443986-15-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.03.054

Reference yield:

2-(3-bromophenyl)-1-(2-methoxyphenyl)ethanone (1178790-92-5) → 3-(3'-hydroxybiphenyl-3-yl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine (1443986-15-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen bromide; bromine / water; chloroform / 20 °C

2.1: 1,2-dimethoxyethane / 20 °C

2.2: Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 4 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; bromine; sodium carbonate; In 1,2-dimethoxyethane; chloroform; water; 3.1: |Suzuki Coupling;

DOI:10.1016/j.ejmech.2013.03.054

Reference yield:

2-bromo-2-(3-bromophenyl)-1-(2-methoxyphenyl)ethanone (1443986-43-3) → 3-(3'-hydroxybiphenyl-3-yl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine (1443986-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-dimethoxyethane / 20 °C

1.2: Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 4 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; 2.1: |Suzuki Coupling;

DOI:10.1016/j.ejmech.2013.03.054

upstream raw materials:

2-bromo-2-(3-bromophenyl)-1-(2-methoxyphenyl)ethanone

3-(3-bromophenyl)-2-(2-methoxyphenyl)-6-(thien-3-yl)imidazo[1,2-b]pyridazine

3-hydroxyphenylboronic acid

2-(3-bromophenyl)-1-(2-methoxyphenyl)ethanone