(E)-N-(2-(4-(2-methoxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide

Base Information

• Chemical Name: (E)-N-(2-(4-(2-methoxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide
• CAS No.: 1374856-28-6
• Molecular Formula: C₂₇H₂₈F₃N₅O₄
• Molecular Weight: 543.546
• Mol file: 1374856-28-6.mol

Synonyms:(E)-N-(2-(4-(2-methoxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide

Chemical Property of (E)-N-(2-(4-(2-methoxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(2-(4-(2-methoxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide

There total 12 articles about (E)-N-(2-(4-(2-methoxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H23N5O2 (1374857-00-7) + 3-(4-trifluoromethoxyphenyl)acrylic acid (199679-35-1) → (E)-N-(2-(4-(2-methoxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide (1374856-28-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h;

DOI:10.1016/j.bmcl.2012.03.049

Reference yield:

C13H24N2O4 (1233952-96-9) → (E)-N-(2-(4-(2-methoxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide (1374856-28-6)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C

2: triethylamine / methanol / 2 h / Reflux

3: palladium 10% on activated carbon; hydrogen / ethanol / 2 h

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2012.03.049

Reference yield:

2-methoxy-N-(4-piperidyl)acetamide (953756-47-3) → (E)-N-(2-(4-(2-methoxyacetamido)piperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide (1374856-28-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / methanol / 2 h / Reflux

2: palladium 10% on activated carbon; hydrogen / ethanol / 2 h

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2012.03.049

upstream raw materials:

2-chloro-4-methyl-6-nitroquinazoline

C₁₃H₂₄N₂O₄

2-methoxy-N-(4-piperidyl)acetamide

C₁₇H₂₁N₅O₄