2-methyl-1-phenylpyrrole-3,4-dicarboxylic acid 3-ethyl ester

Base Information

• Chemical Name: 2-methyl-1-phenylpyrrole-3,4-dicarboxylic acid 3-ethyl ester
• CAS No.: 76526-94-8
• Molecular Formula: C₁₅H₁₅NO₄
• Molecular Weight: 273.288
• Mol file: 76526-94-8.mol

Synonyms:2-methyl-1-phenylpyrrole-3,4-dicarboxylic acid 3-ethyl ester

Chemical Property of 2-methyl-1-phenylpyrrole-3,4-dicarboxylic acid 3-ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-methyl-1-phenylpyrrole-3,4-dicarboxylic acid 3-ethyl ester

There total 3 articles about 2-methyl-1-phenylpyrrole-3,4-dicarboxylic acid 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

diethyl 2-methyl-1-phenylpyrrole-3,4-dicarboxylate (76526-93-7) → 2-methyl-1-phenylpyrrole-3,4-dicarboxylic acid 3-ethyl ester (76526-94-8)

Guidance literature:

With potassium hydroxide; In ethanol; Ambient temperature;

DOI:10.1016/0040-4020(80)80102-5

Reference yield:

ethyl Bromopyruvate (70-23-5) → 2-methyl-1-phenylpyrrole-3,4-dicarboxylic acid 3-ethyl ester (76526-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / ethanol / 0.33 h / Heating

2: 55 percent / KOH / ethanol / Ambient temperature

With potassium hydroxide; In ethanol;

DOI:10.1016/0040-4020(80)80102-5

Reference yield:

(E)-ethyl 3-(phenylamino)but-2-enoate (17469-23-7) → 2-methyl-1-phenylpyrrole-3,4-dicarboxylic acid 3-ethyl ester (76526-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / ethanol / 0.33 h / Heating

2: 55 percent / KOH / ethanol / Ambient temperature

With potassium hydroxide; In ethanol;

DOI:10.1016/0040-4020(80)80102-5

upstream raw materials:

diethyl 2-methyl-1-phenylpyrrole-3,4-dicarboxylate

ethyl Bromopyruvate

(E)-ethyl 3-(phenylamino)but-2-enoate