5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

Base Information

Chemical Name:5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester
CAS No.:134308-64-8
Molecular Formula:C₄₁H₅₀N₄O₈S
Molecular Weight:758.936
Hs Code.:

5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

Synonyms:5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

Suppliers and Price of 5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

There total 22 articles about 5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40052-13-9
mono-tert-butyl malonate

: 134308-64-8
5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / 4-(dimethylamino)pyridine, N-methylmorpholine, 50percent propylphosphonic acid anhydride / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) N-isopropylcyclohexylamine, tert-butyllithium, 2.) Br₂ / 1.) abs. THF, n-hexane, -40 deg C, 30 min, 2.) abs. THF, -78 deg C

3: 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 0.33 h / 0 °C

4: triethylphosphite / 2 h / 80 °C

5: piperidine / <(C₆H₅)3P>4Pd / tetrahydrofuran / 2 h / Ambient temperature

6: N-bromosuccinimide / CH₂Cl₂ / 0.33 h / Ambient temperature

7: 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂; acetonitrile / 0.67 h / Ambient temperature

With piperidine; 4-methyl-morpholine; dmap; N-Bromosuccinimide; N-cyclohexylisopropylamine; bromine; tert.-butyl lithium; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethyl phosphite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 98015-38-4
Brommalonsaeure-allylester-tert-butylester

: 134308-64-8
5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: 1) N-bromosuccinimide, 2) diazabicycloundecen / 1) CH₂Cl₂, room temperature, 20 min, 2) CH₃CN, room temperature, 40 min

With N-Bromosuccinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene;

Reference yield:

: 134308-63-7
(3S,5R)-5-Cyan-4,4,5-trimethyl-2-thioxopyrrolidin-3-propionsaeure-methylester

: 134308-64-8
5-[5-{tert-Butoxycarbonyl-[(3S,5R)-5-cyano-3-(2-methoxycarbonyl-ethyl)-4,4,5-trimethyl-pyrrolidin-(2E)-ylidene]-methylsulfanyl}-4-(2-methoxycarbonyl-ethyl)-3-methyl-pyrrol-(2Z)-ylidenemethyl]-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: 1) N-bromosuccinimide, 2) diazabicycloundecen / 1) CH₂Cl₂, room temperature, 20 min, 2) CH₃CN, room temperature, 40 min

With N-Bromosuccinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene;