lithium 3-(2-(2-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

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Chemical Name:lithium 3-(2-(2-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate
CAS No.:1393900-99-6
Molecular Formula:C₂₉H₃₁F₃N₅O₄*Li
Molecular Weight:577.532
Hs Code.:

Synonyms:lithium 3-(2-(2-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

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Chemical Property of lithium 3-(2-(2-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

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Technology Process of lithium 3-(2-(2-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

There total 11 articles about lithium 3-(2-(2-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1393900-98-5
tert-butyl 4-(4-((4-(3-(methoxycarbonyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperazine-1-carboxylate

: 1393900-99-6
lithium 3-(2-(2-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 17h;

Reference yield:

: 182618-86-6
tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

: 1393900-99-6
lithium 3-(2-(2-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 42 h / 20 °C / Inert atmosphere

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.83 h / 0 °C

2.2: 18 h / 0 - 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon / ethyl acetate; N,N-dimethyl-formamide / 38 h / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 17 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; triethylamine; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 170911-92-9
4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine

: 1393900-99-6
lithium 3-(2-(2-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.83 h / 0 °C

1.2: 18 h / 0 - 20 °C

2.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

3.1: hydrogen / palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon / ethyl acetate; N,N-dimethyl-formamide / 38 h / 20 °C / Inert atmosphere

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 17 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; triethylamine; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;